Evidence map›Paper›PMID 22162817›Full record

ArticleBiomedical optics express2011

Video-rate fluorescence diffuse optical tomography for in vivo sentinel lymph node imaging.

Metasebya Solomon, Brian R White, Ralph E Nothdruft, Walter Akers, Gail Sudlow, Adam T Eggebrecht, Samuel Achilefu, Joseph P Culver

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

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  11. Multimodal fluorescence-mediated tomography and SPECT/CT for small-animal imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2013
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Metasebya Solomon
Brian R White
Ralph E Nothdruft
Walter Akers
Gail Sudlow
Adam T Eggebrecht
Samuel Achilefu
Joseph P Culver
Washington University in St. Louis · US

Funding

Task Specific Project 3: Diffuse Optical TomographyU54CA136398 · NCI · WASHINGTON UNIVERSITY · PI WANG, LIHONG · 2008 to 2012
$6.0M
HIGH-SENSITIVITY DOT FOR MAPPING HUMAN BRAIN FUNCTIONR01EB009233 · NIBIB · WASHINGTON UNIVERSITY · PI CULVER, JOSEPH P · 2009 to 2012
$1.6M
Quantitative Optical Imaging of Molecular Processes in Preclinical Cancer ModelsK01OD010935 · OD · WASHINGTON UNIVERSITY · PI AKERS, WALTER JOHN · 2012 to 2014
$361k
Quantitative Optical Imaging of Molecular Processes in Preclinical Cancer ModelsK01RR026095 · NCRR · WASHINGTON UNIVERSITY · PI AKERS, WALTER JOHN · 2010 to 2011
$245k
NCI NIH HHS U54 CA136398NCRR NIH HHS K01 RR026095NIBIB NIH HHS R01 EB009233NIH HHS K01 OD010935
6 · The paper itself

Abstract

We have developed a fiber-based, video-rate fluorescence diffuse optical tomography (DOT) system for noninvasive in vivo sentinel lymph node (SLN) mapping. Concurrent acquisition of fluorescence and reference signals allowed the efficient generation of ratio-metric data for 3D image reconstruction. Accurate depth localization and high sensitivity to fluorescent targets were established in to depths of >10 mm. In vivo accumulation of indocyanine green (ICG) dye was imaged in the region of the SLN following intradermal injection into the forepaw of rats. These results suggest that video-rate fluorescence DOT has significant potential as a clinical tool for noninvasive mapping of SLN.

Indexed as

(170.0170) Medical optics and biotechnology(170.3660) Light propagation in tissues(170.3880) Medical and biological imaging(170.5270) Photon density waves(170.6510) Spectroscopy, tissue diagnostics

Identifiers

PMID22162817
PMCPMC3233246
OpenAlexW2063709657

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.