ArticleBiomedical optics express2011
Blood testing at the single cell level using quantitative phase and amplitude microscopy.
Article in Biomedical optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Quantitative Analysis of Droplet Evaporation Based on Wedge Prism Digital Holographic Microscope.Micromachines · 2025Article
- Quantitative phase imaging techniques for measuring scattering properties of cells and tissues: a review-part I.Journal of biomedical optics · 2024Review
- Quantitative Measurements of Red Blood Cell Indices Using Spectroscopic Differential Phase-Contrast Microscopy.Chemical & biomedical imaging · 2023Article
- Investigating the Joint Amplitude and Phase Imaging of Stained Samples in Automatic Diagnosis.Sensors (Basel, Switzerland) · 2023Article
- Time-Resolved Four-Channel Jones Matrix Measurement of Birefringent Materials Using an Ultrafast Laser.Materials (Basel, Switzerland) · 2022Article
- Hemoglobin quantification in red blood cells via dry mass mapping based on UV absorption.Journal of biomedical optics · 2021Article
- Optical Investigation of Individual Red Blood Cells for Determining Cell Count and Cellular Hemoglobin Concentration in a Microfluidic Channel.Micromachines · 2021Article
- Quantitative absorption imaging of red blood cells to determine physical and mechanical properties.RSC advances · 2020Article
- Label-free classification of cells based on supervised machine learning of subcellular structures.PloS one · 2019Article
- Three-dimensional quantitative phase imaging of blood coagulation structures by optical projection tomography in flow cytometry using digital holographic microscopy.Journal of biomedical optics · 2018Article
- Wavefront division digital holographic microscopy.Biomedical optics express · 2018Article
- A Time-lapse, Label-free, Quantitative Phase Imaging Study of Dormant and Active Human Cancer Cells.Journal of visualized experiments : JoVE · 2018Article
- Tomographic flow cytometry by digital holography.Light, science & applications · 2017Article
- Multimodal discrimination of immune cells using a combination of Raman spectroscopy and digital holographic microscopy.Scientific reports · 2017Article
- Article
- Single-cell measurement of red blood cell oxygen affinity.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Quantitative phase imaging of arthropods.Journal of biomedical optics · 2015Article
- Review
- Quantitative absorption cytometry for measuring red blood cell hemoglobin mass and volume.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2014Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
It has recently been shown that quantitative phase imaging methods can provide clinically relevant parameters for red blood cell analysis with unprecedented detail and sensitivity. Since the quantitative phase information is dependent on both the thickness and refractive index, a major limitation to clinical translation has been a simple and practical approach to measure both simultaneously. Here we demonstrate both theoretically and experimentally that, by combining quantitative phase with a single absorption measurement, it is possible to measure both quantities at the single cell level. We validate this approach by comparing our results to those acquired using a clinical blood analyzer. This approach to decouple the thickness and refractive index for red blood cells may be used with any quantitative phase imaging method that can operate in tandem with bright field microscopy at the Soret-band wavelength.
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Registered trials
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