ArticleInternational journal of physiology, pathophysiology and pharmacology2011
Modulation of acid-sensing ion channels: molecular mechanisms and therapeutic potential.
Article in International journal of physiology, pathophysiology and pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 59 citations in OpenAlex.
- Acid-sensing ion channels as sensors of brain metabolic state.Pflugers Archiv : European journal of physiology · 2026Review
- Diuretic inhibition of experimental myopia implicates retinal ion-driven efflux in the regulation of ocular growth.Frontiers in medicine · 2026Article
- The Role of Zinc in Modulating Acid-Sensing Ion Channel Function.Biomolecules · 2023Review
- Interfaces Based on Laser-Structured Arrays of Carbon Nanotubes with Albumin for Electrical Stimulation of Heart Cell Growth.Polymers · 2022Article
- A proteomic study to unveil lead toxicity-induced memory impairments invoked by synaptic dysregulation.Toxicology reports · 2022Article
- Acid-Sensing Ion Channels and Mechanosensation.International journal of molecular sciences · 2021Review
- Histidine Residues Are Responsible for Bidirectional Effects of Zinc on Acid-Sensing Ion Channel 1a/3 Heteromeric Channels.Biomolecules · 2020Article
- Therapeutic Effect of Agmatine on Neurological Disease: Focus on Ion Channels and Receptors.Neurochemical research · 2019Review
- Abnormal response of costal chondrocytes to acidosis in patients with chest wall deformity.Experimental and molecular pathology · 2019Article
- Clustered CaCell reports · 2018Article
- The synaptic action of Degenerin/Epithelial sodium channels.Channels (Austin, Tex.) · 2018Review
- Astrocytic Acid-Sensing Ion Channel 1a Contributes to the Development of Chronic Epileptogenesis.Scientific reports · 2016Article
- Article
- Acid-sensing ion channels: potential therapeutic targets for neurologic diseases.Translational neurodegeneration · 2015Article
- Amiloride and SN-6 suppress audiogenic seizure susceptibility in genetically epilepsy-prone rats.CNS neuroscience & therapeutics · 2014Article
- Histamine mediates behavioural and metabolic effects of 3-iodothyroacetic acid, an endogenous end product of thyroid hormone metabolism.British journal of pharmacology · 2014Article
- Acid-sensing ion channels in mouse olfactory bulb M/T neurons.The Journal of general physiology · 2014Article
- Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke?Progress in neurobiology · 2014Review
- Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli.Genes, brain, and behavior · 2014Article
- Translational strategies for neuroprotection in ischemic stroke--focusing on acid-sensing ion channel 1a.Translational stroke research · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Increases in extracellular proton concentrations, which takes place in physiological conditions such as synaptic signaling and pathological conditions such as tissue inflammation, ischemic stroke, traumatic brain injury, and epileptic seizure, activates a unique family of membrane ion channels; the acid-sensing ion channels (ASICs). All ASICs belong to amiloride-sensitive degenerin/epithelial Na(+) channel superfamily. Four genes encoded at seven sub-units have been identified. ASICs are expressed primarily in neurons and have been shown to play critical roles in synaptic plasticity, learning/memory, fear conditioning, sensory transduction, pain perception, ischemic brain injury, seizure, and other neurological as well as psychological disorders. Although protons are the primary activator for ASICs, the properties and/or level of expression of these channels are modulated dramatically by neuropeptides, di-and polyvalent cations, inflammatory mediators, associated proteins, and protein phosphorylations, etc. Modulation of ASICs can result in profound changes in the activities and functions of these channels in both physiological and pathological processes. In this article, we provide an up to date review on the modulations of ASICs by exogenous agents and endogenous signaling molecules. A better understanding of how ASICs can be modulated should help define new strategies to counteract the deleterious effects of dysregulated ASIC activity.
Indexed as
Identifiers
22162785PMC3230262W196279351What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.