ArticlePloS one2011
Dopamine transporter (DAT1) and dopamine receptor D4 (DRD4) genotypes differentially impact on electrophysiological correlates of error processing.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- The Role of Dopaminergic Genes in Probabilistic Reinforcement Learning in Schizophrenia Spectrum Disorders.Brain sciences · 2021Article
- Establishing norms for error-related brain activity during the arrow Flanker task among young adults.NeuroImage · 2020Article
- Evidence for cerebello-thalamo-cortical hyperconnectivity as a heritable trait for schizophrenia.Translational psychiatry · 2019Article
- Exposing an "Intangible" Cognitive Skill among Collegiate Football Players: Enhanced Interference Control.Frontiers in psychology · 2018Article
- The genetics of anxiety-related negative valence system traits.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- Dissociable genetic contributions to error processing: a multimodal neuroimaging study.PloS one · 2014Article
- Performance monitoring in children and adolescents: a review of developmental changes in the error-related negativity and brain maturation.Developmental cognitive neuroscience · 2013Review
- Neural markers of errors as endophenotypes in neuropsychiatric disorders.Frontiers in human neuroscience · 2013Article
- Additive effects of the dopamine D2 receptor and dopamine transporter genes on the error-related negativity in young children.Genes, brain, and behavior · 2012Article
- An electrophysiological signal that precisely tracks the emergence of error awareness.Frontiers in human neuroscience · 2012Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies as well as theoretical models of error processing assign fundamental importance to the brain's dopaminergic system. Research about how the electrophysiological correlates of error processing--the error-related negativity (ERN) and the error positivity (Pe)--are influenced by variations of common dopaminergic genes, however, is still relatively scarce. In the present study, we therefore investigated whether polymorphisms in the DAT1 gene and in the DRD4 gene, respectively, lead to interindividual differences in these error processing correlates. One hundred sixty participants completed a version of the Eriksen Flanker Task while a 26-channel EEG was recorded. The task was slightly modified in order to increase error rates. During data analysis, participants were split into two groups depending on their DAT1 and their DRD4 genotypes, respectively. ERN and Pe amplitudes after correct responses and after errors as well as difference amplitudes between errors and correct responses were analyzed. We found a differential effect of DAT1 genotype on the Pe difference amplitude but not on the ERN difference amplitude, while the reverse was true for DRD4 genotype. These findings are in line with predictions from theoretical models of dopaminergic transmission in the brain. They furthermore tie results from clinical investigations of disorders impacting on the dopamine system to genetic variations known to be at-risk genotypes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.