ArticleAdvances in pharmacological sciences2012
The anti-inflammatory role of vitamin e in prevention of osteoporosis.
Article in Advances in pharmacological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Tocotrienols Regulate Bone Loss through Suppression on Osteoclast Differentiation and Activity: A Systematic Review.Current drug targets · 2018Pooled it
- Trial
- Changes in nutrient intake and inflammation following an anti-inflammatory diet in spinal cord injury.The journal of spinal cord medicine · 2019Trial
- Trial
- Serum levels of vitamin E, vitamin D, and omega-3 fatty acids in patients with generalized chronic periodontitis: A cross-sectional study.Journal of dental research, dental clinics, dental prospects · 2025Article
- Phytotherapy with Fruit Seed Extracts as a Promising Approach for the Treatment of Inflammation.Current nutrition reports · 2025Review
- The use of vitamin E in ocular health: Bridging omics approaches with Tocopherol and Tocotrienol in the management of glaucoma.Food chemistry. Molecular sciences · 2024Article
- Treatment of Bone Defects and Nonunion via Novel Delivery Mechanisms, Growth Factors, and Stem Cells: A Review.ACS biomaterials science & engineering · 2024Review
- Antox targeting AGE/RAGE cascades to restore submandibular gland viability in rat model of type 1 diabetes.Scientific reports · 2024Article
- Mechanistic Insights and Therapeutic Strategies in Osteoporosis: A Comprehensive Review.Biomedicines · 2024Review
- Emissions from plastic incineration induce inflammation, oxidative stress, and impaired bioenergetics in primary human respiratory epithelial cells.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- The Impact of Antioxidants on Vitiligo and Melasma: A Scoping Review and Meta-Analysis.Antioxidants (Basel, Switzerland) · 2023Article
- Ameliorative Effect of Tocotrienols on Perimenopausal-Associated Osteoporosis-A Review.Antioxidants (Basel, Switzerland) · 2022Review
- In Vitro and In Vivo Anti-Arthritic Potential ofMolecules (Basel, Switzerland) · 2022Article
- Active Compounds in Fruits and Inflammation in the Body.Nutrients · 2022Review
- The Effect of α-Tocopherol on the Reduction of Inflammatory Processes and the Negative Effect of Acrylamide.Molecules (Basel, Switzerland) · 2022Article
- Three Classes of Antioxidant Defense Systems and the Development of Postmenopausal Osteoporosis.Frontiers in physiology · 2022Review
- The Cytokine and Bone Protein Expression by Ellagic Acid-Hydroxyapatite in Bone Remodelling Model.TheScientificWorldJournal · 2022Article
- Vitamin E: A Review of Its Application and Methods of Detection When Combined with Implant Biomaterials.Materials (Basel, Switzerland) · 2021Review
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is growing evidence that inflammation may be one of the causal factors of osteoporosis. Several cytokines such as IL-1, IL-6, RANKL, OPG, and M-CSF were implicated in the pathogenesis of osteoporosis. These cytokines are important determinants of osteoclast differentiation and its bone resorptive activity. Anticytokine therapy using cytokine antagonists such as IL-receptor antagonist and TNF-binding protein was able to suppress the activity of the respective cytokines and prevent bone loss. Several animal studies have shown that vitamin E in the forms of palm-derived tocotrienol and α-tocopherol may prevent osteoporosis in rat models by suppressing IL-1 and IL-6. Free radicals are known to activate transcription factor NFκB which leads to the production of bone resorbing cytokines. Vitamin E, a potent antioxidant, may be able to neutralise free radicals before they could activate NFκB, therefore suppressing cytokine production and osteoporosis. Vitamin E has also been shown to inhibit COX-2, the enzyme involved in inflammatory reactions. Of the two types of vitamin E studied, tocotrienol seemed to be better than tocopherol in terms of its ability to suppress bone-resorbing cytokines.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.