Evidence map›Paper›PMID 22162551›Full record

ArticleJournal of clinical microbiology2012

Aerosolized vaccine as an unexpected source of false-positive Bordetella pertussis PCR results.

Hossein Salimnia, Paul R Lephart, Basim I Asmar, Dawn Prebelich, Erin Paulson, Marilynn R Fairfax

Abstract read
In one paragraph

Article in Journal of clinical microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Multicenter Clinical Evaluation of the Automated AriesJournal of clinical microbiology · 2019
    Article
  4. Article
  5. Laboratory Diagnosis of Pertussis.Clinical microbiology reviews · 2015
    Review
  6. Diagnostic molecular microbiology: a 2013 snapshot.Clinics in laboratory medicine · 2013
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hossein SalimniaDetroit Medical Center University Laboratories, Detroit, Michigan, USA.
Paul R Lephart
Basim I Asmar
Dawn Prebelich
Erin Paulson
Marilynn R Fairfax

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

When 13 of 13 nasal wash specimens from a single pediatrician's office tested positive for low quantities of Bordetella pertussis DNA, we suspected prelaboratory contamination. Investigation revealed that Pentacel and Adacel vaccines contain high copy numbers of B. pertussis DNA, which can be aerosolized, causing false-positive B. pertussis PCR results.

Indexed as

AerosolsFalse Positive ReactionsBordetella pertussisHumansPertussis VaccinePolymerase Chain ReactionWhooping CoughAerosolsPertussis Vaccine

Identifiers

PMID22162551
PMCPMC3264183

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.