ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2012
Genetic and environmental contributions to self-reported thoughts of self-harm and suicide.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Intragenic deletions from whole genome sequencing of 1054 suicide deaths.Research square · 2026Article
- Hormonal contraception and the risk of suicidal behaviour: a Swedish nationwide register-based study.BMJ open · 2025Article
- Understanding the interplay of Caesarean delivery and genetic influences on intelligence and anxiety traits in offspring findings from genome-wide association studies.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- Associations between physical activities and self-harm behaviour in depression across the genotype: findings from the UK biobank.BJPsych open · 2025Article
- The role of substance use disorders in the transition from suicide attempt to suicide death: a record linkage study of a Swedish cohort.Psychological medicine · 2024Article
- Genetic differences between suicide deaths and deaths of undetermined intent.Suicide & life-threatening behavior · 2023Article
- Examining protective factors for substance use problems and self-harm behavior during adolescence: A longitudinal co-twin control study.Development and psychopathology · 2022Article
- Suicidal ideation during adolescence: The roles of aggregate genetic liability for suicide attempts and negative life events in the past year.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
- The association between body dysmorphic symptoms and suicidality among adolescents and young adults: a genetically informative study.Psychological medicine · 2022Article
- Genetic propensity for risky behavior and depression and risk of lifetime suicide attempt among urban African Americans in adolescence and young adulthood.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2021Article
- On the Genetic and Environmental Relationship Between Suicide Attempt and Death by Suicide.The American journal of psychiatry · 2021Article
- The Co-occurrence of Self-Harm and Aggression: A Cognitive-Emotional Model of Dual-Harm.Frontiers in psychology · 2021Article
- The association between general childhood psychopathology and adolescent suicide attempt and self-harm: A prospective, population-based twin study.Journal of abnormal psychology · 2020Article
- Ethical implications of using biobanks and population databases for genetic suicide research.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Review
- Genetic and environmental sources of covariation between early drinking and adult functioning.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2017Article
- Genetic Association Studies of Suicidal Behavior: A Review of the Past 10 Years, Progress, Limitations, and Future Directions.Frontiers in psychiatry · 2016Review
- Genetic risk factors in two Utah pedigrees at high risk for suicide.Translational psychiatry · 2013Article
- Suicidal Behavior and Neurological Illnesses.Journal of depression & anxiety · 2013Article
- Gene-environment studies and borderline personality disorder: a review.Current psychiatry reports · 2013Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Thoughts of self-harm and suicidal behavior are thought to be influenced by both genetics and environment. Molecular genetic studies are beginning to address the question of which genes may be involved and whether different genes may be expressed in men and women. We examined thoughts of self-harm and suicidal behavior in a large general population twin sample including male and female same- and opposite-sex twins. In this study, data on self-reported thoughts of self-harm and suicide were obtained from self-report questionnaires (Beck Depression Inventory and Youth or Adult Self Report forms) in 6,265 twin pairs (11,008 individuals) aged 11-90 (62% female) from the Netherlands Twin Registry. Liability threshold models were compared including sex and age (linear and quadratic) effects. Models were compared using measures of parsimony to calculate the simplest model to the data. A model with additive genetic and unique environmental contributions fitted the data for both males and females. There were no qualitative sex differences, but the relative contributions differed between men and women. Heritability was higher in women (0.74, 95% CI 0.65-0.81) than men (0.45, 95% CI 0.28-0.61). The remaining variance was accounted for by environmental influence unique to an individual. These results suggest contributions from additive genetic factors to self-reported thoughts of self-harm and suicide and support the continued study of both molecular genetic and individual-specific environmental risk factors.
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Registered trials
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