Evidence map›Paper›PMID 22162397›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2012

Designer hydrophilic regions regulate droplet shape for controlled surface patterning and 3D microgel synthesis.

Matthew J Hancock, Fumiki Yanagawa, Yun-Ho Jang, Jiankang He, Nezamoddin N Kachouie, Hirokazu Kaji, Ali Khademhosseini

Abstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthew J HancockCenter for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA.
Fumiki Yanagawa
Yun-Ho Jang
Jiankang He
Nezamoddin N Kachouie
Hirokazu Kaji
Ali Khademhosseini

Funding

Microengineered Osteons for Bone Tissue EngineeringR01AR057837 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YANG, YUNZHI · 2010 to 2018
$5.1M
3D combinatorial microenvironments for effective cell based therapyR01HL099073 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI, LIAO, RONGLIH · 2010 to 2013
$2.6M
Microfabricated Vascularized 3D Tissue Engineered ConstructsR01HL092836 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI · 2008 to 2012
$2.4M
Microengineered environments for epithelial-mesenchymal interactions (SysCODE 7RL1DE019024 · NIDCR · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI · 2007 to 2011
$1.9M
Engineering Vascularized Bone Tissues By Microfabrication And ScaffoldingR01DE021468 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YANG, YUNZHI · 2011 to 2014
$1.8M
A Microfabrication Platform for Direct Printing Vascularized Functional Tissue CoR01EB012597 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN · 2010 to 2013
$1.4M
MICROFLUIDIC SYSTEM FOR SCREENING STEM CELL MICROENVIRONMENTSR01EB008392 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI · 2009 to 2010
$820k
NHLBI NIH HHS HL092836NHLBI NIH HHS HL099073NHLBI NIH HHS R01 HL092836NHLBI NIH HHS R01 HL099073NIAMS NIH HHS R01 AR057837NIBIB NIH HHS EB008392NIBIB NIH HHS EB012597NIBIB NIH HHS R01 EB008392NIBIB NIH HHS R01 EB012597NIDCR NIH HHS DE019024NIDCR NIH HHS DE021468NIDCR NIH HHS R01 DE021468NIDCR NIH HHS RL1 DE019024
6 · The paper itself

Abstract

A simple technique is presented for controlling the shapes of micro- and nanodrops by patterning surfaces with special hydrophilic regions surrounded by hydrophobic boundaries. Finite element method simulations link the shape of the hydrophilic regions to that of the droplets. Shaped droplets are used to controllably pattern planar surfaces and microwell arrays with microparticles and cells at the micro- and macroscales. Droplets containing suspended sedimenting particles, initially at uniform concentration, deposit more particles under deeper regions than under shallow regions. The resulting surface concentration is thus proportional to the local fluid depth and agrees well with the measured and simulated droplet profiles. A second application is also highlighted in which shaped droplets of prepolymer solution are crosslinked to synthesize microgels with tailored 3D geometry.

Indexed as

Hydrophobic and Hydrophilic InteractionsAnimalsGelsMiceMicroscopy, Electron, ScanningNanotechnologyNIH 3T3 CellsSurface PropertiesGels

Identifiers

PMID22162397
PMCPMC3285541

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.