ReviewMolecular carcinogenesis2012
Is dietary fat, vitamin D, or folate associated with pancreatic cancer?
Review in Molecular carcinogenesis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- The association between circulating 25-hydroxyvitamin D and pancreatic cancer: a systematic review and meta-analysis of observational studies.European journal of nutrition · 2024Pooled it
- Dietary Patterns and Pancreatic Cancer Risk: A Meta-Analysis.Nutrients · 2017Pooled it
- Low-fat Dietary Pattern and Pancreatic Cancer Risk in the Women's Health Initiative Dietary Modification Randomized Controlled Trial.Journal of the National Cancer Institute · 2018Trial
- The role of the folate pathway in pancreatic cancer risk.PloS one · 2018Trial
- Global and regional disparities in the burden of disease and risk factors between pancreatitis and pancreatic cancer: a systematic analysis for the global burden of disease study.BMC gastroenterology · 2026Article
- Dietary Patterns of Insulinemia, Inflammation and Glycemia, and Pancreatic Cancer Risk: Findings from the Women's Health Initiative.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- The potential roles of exosomes in pancreatic cancer initiation and metastasis.Molecular cancer · 2020Review
- A Prospective Analysis of Intake of Red and Processed Meat in Relation to Pancreatic Cancer among African American Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Heterogeneous Effects of Calorie Content and Nutritional Components Underlie Dietary Influence on Pancreatic Cancer Susceptibility.Cell reports · 2020Article
- Correlation between Oxidative Stress, Nutrition, and Cancer Initiation.International journal of molecular sciences · 2017Review
- Modeling gene-wise dependencies improves the identification of drug response biomarkers in cancer studies.Bioinformatics (Oxford, England) · 2017Article
- Retrospective analysis of the influence of 25-hydroxyvitamin D on disease progression and survival in pancreatic cancer.Nutrition journal · 2016Article
- Adjuvant, neoadjuvant, and experimental regimens in overcoming pancreatic ductal adenocarcinoma.Przeglad gastroenterologiczny · 2016Review
- Article
- High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model.Cancer prevention research (Philadelphia, Pa.) · 2013Article
- Article
- Influence of diet and tobacco smoking on pancreatic cancer incidence in poland in 1960-2008.Gastroenterology research and practice · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Although potentially modifiable risk factors for pancreatic cancer include smoking, obesity, and diabetes, less is known about the extent to which diet affects cancer risk. Recent studies have demonstrated some consistency for dietary fat being associated with elevated pancreatic cancer risk, particularly from animal sources. However, less is known about which fatty acids pose the greatest risk. Vitamin D, due to its endogenous production following UV-B exposure, is a unique risk factor in that researchers have created several methods to assess its exposure in humans. Studies that measured vitamin D exposure differently have shown inconsistent results. Dietary studies suggest protective associations, whereas studies of circulating 25-hydroxyvitamin D status show null or positive associations with low or very high concentrations, respectively. Several, but not all epidemiologic studies provide evidence of an inverse relationship between total and/or dietary folate and risk of pancreatic cancer. Protective associations for circulating folate are more often observed among populations with inadequate status. This article reviews the current epidemiological and experimental evidence investigating the relationship of dietary fat, vitamin D, and folate with pancreatic cancer. Additionally the mechanisms by which these risk factors may contribute to cancer, the methodological challenges involved with assessing risk, and other obstacles encountered when ascertaining the magnitude and direction of these three exposures are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.