Evidence map›Paper›PMID 22162214›Full record

ArticleChembiochem : a European journal of chemical biology2011

Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry.

Camelia Vlad, Kathrin Lindner, Christiaan Karreman, Stefan Schildknecht, Marcel Leist, Nick Tomczyk, John Rontree, James Langridge, Karin Danzer, Thomas Ciossek and 4 more

Open access · greenAbstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Diagnostic Potential of Amyloidogenic Proteins.International journal of molecular sciences · 2021
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Dopamine-induced α-synuclein oligomers show self- and cross-propagation properties.Protein science : a publication of the Protein Society · 2014
    Article
  15. Article
  16. Thioamide-based fluorescent protease sensors.Journal of the American Chemical Society · 2014
    Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Camelia VladDepartment of Chemistry, University of Konstanz, 78457 Konstanz, Germany.
Kathrin Lindner
Christiaan Karreman
Stefan Schildknecht
Marcel Leist
Nick Tomczyk
John Rontree
James Langridge
Karin Danzer
Thomas Ciossek
Alina Petre
Michael L Gross
Bastian Hengerer
Michael Przybylski
University of Konstanz · DEBoehringer Ingelheim (Germany) · DEWaters (United Kingdom) · GBWashington University in St. Louis · US

Funding

YOGA LIFESTYLE INTERVENTION REDUCES BLOOD PRESSURE IN HIV-INFECTED ADULTSP41RR000954 · NCRR · WASHINGTON UNIVERSITY · PI LIN, XI · 1985 to 2011
$16.0M
TrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0M
NCRR NIH HHS P41 RR000954NCRR NIH HHS P41RR000954NIGMS NIH HHS P41 GM103422
6 · The paper itself

Abstract

Gas-phase protein separation by ion mobility: With its ability to separate the Parkinson's disease protein α-synuclein and its autoproteolytic products-despite the small concentrations of the latter-ion-mobility MS has enabled the characterization of intermediate fragments in in vitro oligomerization-aggregation. In particular, a possible key fragment, the highly aggregating C-terminal fragment, αSyn(72-140), has been revealed.

Indexed as

alpha-SynucleinBiopolymersChromatography, High Pressure LiquidElectrophoresis, Polyacrylamide GelHumansMass SpectrometryParkinson DiseaseProteolysisSpectrometry, Mass, Electrospray IonizationTandem Mass Spectrometryalpha-SynucleinBiopolymers

Identifiers

PMID22162214
PMCPMC3461308
OpenAlexW1987917217

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.