ArticleInternational journal of cancer2012
Race and prevalence of human papillomavirus infection among men residing in Brazil, Mexico and the United States.
Article in International journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Global and regional estimates of genital human papillomavirus prevalence among men: a systematic review and meta-analysis.The Lancet. Global health · 2023Pooled it
- Prevalence and Risk Factors of Human Papillomavirus in Male Patients: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2018Pooled it
- Epidemiology and Prognostic Role of HPV Infection in Head and Neck Cancer: A Population-Based Study of the SEER Database.Cancer medicine · 2025Article
- Genital Human Papillomavirus Prevalence and Genotyping Among Males in Putuo District of Shanghai, China 2015-2019.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
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- Variants in immune-related genes and genital HPV 16 persistence in men.Papillomavirus research (Amsterdam, Netherlands) · 2019Article
- Role of histological findings and pathologic diagnosis for detection of human papillomavirus infection in men.Journal of medical virology · 2015Article
- High genital prevalence of cutaneous human papillomavirus DNA on male genital skin: the HPV Infection in Men Study.BMC infectious diseases · 2014Article
- Age-related variation in sexual behaviours among heterosexual men residing in Brazil, Mexico and the USA.The journal of family planning and reproductive health care · 2014Article
- A prospective analysis of smoking and human papillomavirus infection among men in the HPV in Men Study.International journal of cancer · 2014Article
- Racial differences in the incidence and clearance of human papilloma virus (HPV): the HPV in men (HIM) study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Article
- Broad HPV distribution in the genital region of men from the HPV infection in men (HIM) study.Virology · 2013Article
- HPV related diseases in males: a heavy vaccine-preventable burden.Journal of preventive medicine and hygiene · 2013Review
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
Abstract
Human papillomavirus (HPV) causes anal, penile and oropharyngeal cancers in men. Genital HPV prevalence in men appears to vary by world region with men residing in Asia having among the lowest prevalence. Unfortunately, there is little information on prevalence of HPV infection in men by race. The purpose of this study was to examine HPV prevalence by race across three countries. 3,909 men ages 18-70 years enrolled in an ongoing prospective cohort study of the natural history of HPV in men (The HIM Study) were included in the analysis. Participants completed risk factor questionnaires and samples were taken from the penile epithelium and scrotum for HPV detection. HPV testing of the combined DNA extract was conducted using PCR and genotyping. Asian/Pacific Islanders had the lowest HPV prevalence of 42.2% compared to Blacks (66.2%), and Whites (71.5%). The Asian/Pacific Islander race was strongly protective in univariate analysis (prevalence ratio (PR) = 0.59; 95% confidence interval (CI): 0.48-0.74) and multivariate analysis for any HPV infection (PR = 0.65; 95% CI: 0.52-0.8). Stratified analysis by lifetime number of female partners also showed strong inverse associations with the Asian/Pacific Islander race. We consistently observed the lowest prevalence of HPV infection among Asian/Pacific Islanders with moderate inverse associations even after various adjustments for potential confounding factors. Unmeasured behavioral factors, sexual mixing with low risk women, and/or race-specific differences in the frequency of germline variations among immune regulating genes may underlie these associations. Further studies among Asian populations that incorporate measures of immuno-genetics are needed to understand this phenomenon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.