ArticleInternational journal of cancer2012
Glycated hemoglobin and cancer incidence and mortality in the Atherosclerosis in Communities (ARIC) Study, 1990-2006.
Article in International journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 8 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 8 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Association of Measures of Glucose Metabolism with Colorectal Cancer Risk in Older Chinese: A 13-Year Follow-up of the Guangzhou Biobank Cohort Study-Cardiovascular Disease Substudy and Meta-Analysis.Diabetes & metabolism journal · 2024Pooled it
- Prediabetes and the risk of lung cancer incidence and mortality: A meta-analysis.Journal of diabetes investigation · 2023Pooled it
- Prediabetes and the risk of breast cancer: a meta-analysis.Frontiers in oncology · 2023Pooled it
- Diabetes History and Gastric Cancer Risk: Different Results by Types of Follow-Up Studies.Asian Pacific journal of cancer prevention : APJCP · 2022Pooled it
- Pooled it
- HbA1c and Risks of All-Cause and Cause-Specific Death in Subjects without Known Diabetes: A Dose-Response Meta-Analysis of Prospective Cohort Studies.Scientific reports · 2016Pooled it
- Does cancer risk increase with HbA1c, independent of diabetes?British journal of cancer · 2014Pooled it
- CARING (CAncer Risk and INsulin analoGues): the association of diabetes mellitus and cancer risk with focus on possible determinants - a systematic review and a meta-analysis.Current drug safety · 2013Pooled it
- The effect of barley savigh consumption on blood sugar among pre-diabetic postmenopausal women.Scientific reports · 2025Trial
- Hemoglobin A1c Levels Modify Associations between Dietary Acid Load and Breast Cancer Recurrence.Nutrients · 2020Trial
- Development and Validation of a Clinical Radiomics Nomogram for Predicting Early Recurrence After Microwave Ablation in Hepatocellular Carcinoma Patients With Type 2 Diabetes.Cancer management and research · 2026Article
- Biological organ ages associate with risk of chronic diseases in a community-based population.JCI insight · 2025Article
- Increased colorectal cancer risk in prediabetes: A meta-analysis.World journal of diabetes · 2025Article
- HbABMC cancer · 2025Article
- Association between glycemic control and hepatocellular carcinoma risk in people with type 2 diabetes, stratified by chronic hepatitis B or C infection.Therapeutic advances in gastroenterology · 2025Article
- Association between glucose levels and all-cause mortality in cancer survivors: findings from NHANES 1999-2018.BMC public health · 2024Article
- Age-specific differences in association of glycosylated hemoglobin levels with the prevalence of cardiovascular diseases among nondiabetics: the National Health and Nutrition Examination Survey 2005-2018.BMC cardiovascular disorders · 2024Article
- A low-glucose eating pattern is associated with improvements in glycemic variability among women at risk for postmenopausal breast cancer: an exploratory analysis.Frontiers in nutrition · 2024Article
- Association of Glycosylated Hemoglobin Level and Cancer-Related Mortality in Patients without Diabetes.Journal of clinical medicine · 2022Article
- Prospective associations of hemoglobin ACancer research communications · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Diabetes is a risk factor for many cancers; chronic hyperglycemia is hypothesized to be, in part, explanatory. We evaluated the association between glycated hemoglobin, a time-integrated glycemia measure, and cancer incidence and mortality in nondiabetic and diabetic men and women. We conducted a prospective study of 12,792 cancer-free participants attending the second visit (1990-1992) of the Atherosclerosis Risk in Communities (ARIC) Study. We measured glycated hemoglobin in whole-blood samples using HPLC. Incident cancers were ascertained from registries and hospital records through 2006. We estimated multivariable-adjusted hazard ratios (HR) of cancer incidence and mortality for nondiabetic participants with values ≥ 5.7% (elevated), nondiabetic participants with <5.0% (low) and diabetic participants all compared with nondiabetic participants with 5.0-5.6% (normal). We ascertained 2,349 incident cancer cases and 887 cancer deaths. Compared with nondiabetic women with normal glycated hemoglobin, nondiabetic women with elevated values had an increased risk of cancer incidence (HR:1.24; 95% CI:1.07,1.44) and mortality (HR:1.58; 95% CI:1.23,2.05) as did diabetic women (incidence, HR:1.30; 95% CI:1.06,1.60, mortality, HR:1.96; 95% CI:1.40,2.76). Nondiabetic women with low values also had increased risk. Diabetic women with good glycemic control (<7.0%) had a lower cancer risk than those with higher values. Glycated hemoglobin in nondiabetic and diabetic men, and diabetes were not statistically significantly associated with total cancer risk. Our findings support the hypothesis that chronic hyperglycemia, even in the nondiabetic range, increases cancer risk in women. Maintaining normal glycated hemoglobin overall, and good glycemic control among diabetic adults, may reduce the burden of cancer, especially in women.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.