Evidence map›Paper›PMID 22161726›Full record

Trial reportQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2012

The effect of weight loss on changes in health-related quality of life among overweight and obese women with urinary incontinence.

Angela Marinilli Pinto, Leslee L Subak, Sanae Nakagawa, Eric Vittinghoff, Rena R Wing, John W Kusek, William H Herman, Delia Smith West, Miriam Kuppermann

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Lifestyle interventions for the treatment of urinary incontinence in adults.The Cochrane database of systematic reviews · 2015
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Angela Marinilli PintoPsychology Department, Baruch College, CUNY, 55 Lexington Avenue, B8-215, New York, NY 10010, USA. Angela.Pinto@baruch.cuny.edu
Leslee L Subak
Sanae Nakagawa
Eric Vittinghoff
Rena R Wing
John W Kusek
William H Herman
Delia Smith West
Miriam Kuppermann
University of California, San Francisco · USBaruch College · USBrown University · USNational Institute of Diabetes and Digestive and Kidney Diseases · USUniversidad Católica de Santa Fe · ARUniversity of Arkansas for Medical Sciences · USUniversity of Michigan–Ann Arbor · US

Funding

Research BaseP30DK092926 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARY ELLEN MICHELE HEISLER, ADESUWA B OLOMU · 2011 to 2026
$10.0M
Weight Reduction for Incontinence Network(WIN)U01DK067860 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRADY, DEBORAH G · 2003 to 2007
$2.3M
Weight Reduction for Incontinence NetworkU01DK067861 · NIDDK · MIRIAM HOSPITAL · PI WING, RENA R · 2003 to 2007
$2.2M
Weight Reduction for Incontinence Network (WIN)U01DK067862 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FRANKLIN, FRANK A · 2003 to 2007
$1.7M
Patient Oriented Research and Mentoring in Obesity and Urinary IncontinenceK24DK080775 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SUBAK, LESLEE L · 2008 to 2019
$1.7M
Managing obesity by combining behavioral weight loss and commercial approachesK23DK075645 · NIDDK · BERNARD M. BARUCH COLLEGE · PI PINTO, ANGELA MARINILLI · 2007 to 2010
$640k
NIDDK NIH HHS 5K23DK075645NIDDK NIH HHS K23 DK075645NIDDK NIH HHS K24 DK080775NIDDK NIH HHS P30 DK092926NIDDK NIH HHS #U01 DK067860NIDDK NIH HHS U01 DK067860NIDDK NIH HHS U01 DK067861NIDDK NIH HHS U01 DK067862
6 · The paper itself

Abstract

objectiveTo estimate the effect of change in weight and change in urinary incontinence (UI) frequency on changes in preference-based measures of health-related quality of life (HRQL) among overweight and obese women with UI participating in a weight loss trial.

methodsWe conducted a longitudinal cohort analysis of 338 overweight and obese women with UI enrolled in a randomized clinical trial comparing a behavioral weight loss intervention to an educational control condition. At baseline, 6, and 18 months, health utilities were estimated using the Health Utilities Index Mark 3 (HUI3), a transformation of the SF-36 to the preference-based SF-6D, and the estimated Quality of Well-Being (eQWB) score (a summary calculated from the SF-36 physical functioning, mental health, bodily pain, general health perceptions, and role limitations-physical subscale scores). Potential predictors of changes in these outcomes were examined using generalized estimating equations.

resultsIn adjusted multivariable models, weight loss was associated with improvement in HUI3, SF-6D, and eQWB at 6 and 18 months (P < 0.05). Increases in physical activity also were independently associated with improvement in HUI3 (P = 0.01) and SF-6D (P = 0.006) scores at 18 months. In contrast, reduction in UI frequency did not predict improvements in HRQL at 6 or 18 months.

conclusionWeight loss and increased physical activity, but not reduction in UI frequency, were strongly associated with improvements in health utilities measured by the HUI3, SF-6D, and eQWB. These findings provide important information that can be used to inform cost-utility analyses of weight loss interventions.

Indexed as

Quality of LifeWeight LossAdultBehavior TherapyCohort StudiesFemaleHumansLongitudinal StudiesMiddle AgedObesityOverweightUrinary Incontinence

Identifiers

PMID22161726
PMCPMC3375350
OpenAlexW2088480402

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.