SynthesisThe Cochrane database of systematic reviews2011
Physical training for McArdle disease.
Synthesis in The Cochrane database of systematic reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Interventions for promoting physical activity in people with neuromuscular disease.The Cochrane database of systematic reviews · 2021Pooled it
- Targeted Therapies for Metabolic Myopathies Related to Glycogen Storage and Lipid Metabolism: a Systematic Review and Steps Towards a 'Treatabolome'.Journal of neuromuscular diseases · 2021Pooled it
- Measuring the effects of exercise in neuromuscular disorders: a systematic review and meta-analyses.Wellcome open research · 2020Pooled it
- Strength training and aerobic exercise training for muscle disease.The Cochrane database of systematic reviews · 2019Pooled it
- Pharmacological and nutritional treatment for McArdle disease (Glycogen Storage Disease type V).The Cochrane database of systematic reviews · 2014Pooled it
- Low-carbohydrate ketogenic diet in Mc Ardle's disease: a single-blinded randomized controlled trial.Journal of neurology · 2025Trial
- Physical exercise in metabolic myopathies at risk of rhabdomyolysis: a feasible approach or an unavoidable hazard?European journal of applied physiology · 2025Review
- Late Presentation of McArdle's Disease Mimicking Polymyalgia Rheumatica: A Case Report and Review of the Literature.Case reports in rheumatology · 2025Article
- Toward an Understanding of GSD5 (McArdle disease): How Do Individuals Learn to Live with the Metabolic Defect in Daily Life.Journal of neuromuscular diseases · 2024Article
- Diagnosis and management of children with McArdle Syndrome (GSD V) in New South Wales.JIMD reports · 2023Article
- Data from the European registry for patients with McArdle disease (EUROMAC): functional status and social participation.Orphanet journal of rare diseases · 2023Article
- Pretreatment of rhesus monkeys with transdermal patches containing physostigmine and procyclidine: implications of the delivery system for the potential application against VX nerve agent intoxication in humans.Archives of toxicology · 2023Article
- Proposing a Core Outcome Set for Physical Activity and Exercise Interventions in People With Rare Neurological Conditions.Frontiers in rehabilitation sciences · 2021Article
- Sex Differences and the Influence of an Active Lifestyle on Adiposity in Patients with McArdle Disease.International journal of environmental research and public health · 2020Article
- Myopathies Related to Glycogen Metabolism Disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- Wave of renal impairment.BMJ case reports · 2018Article
- Safety and efficacy of exercise training in adults with Pompe disease: evalution of endurance, muscle strength and core stability before and after a 12 week training program.Orphanet journal of rare diseases · 2015Article
- Exercise in muscle glycogen storage diseases.Journal of inherited metabolic disease · 2015Review
- Emotionally-intense situations can result in rhabdomyolysis in McArdle disease.BMJ case reports · 2014Article
- McArdle Disease and Exercise Physiology.Biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMcArdle disease is a rare metabolic myopathy caused by a complete absence of the enzyme muscle glycogen phosphorylase. Affected people experience symptoms of fatigue and cramping within minutes of exercise and are at risk for acute muscle injury (rhabdomyolysis) and acute renal failure. If the first few minutes of exercise are paced, a 'second wind' will occur enabling exercise to continue. This is due to mobilisation and utilisation of alternative fuel substrates. Aerobic training appears to improve work capacity by increasing cardiovascular fitness.
objectivesTo assess the effects of aerobic training in people with McArdle disease. SEARCH
methodsWe searched the Cochrane Neuromuscular Disease Group Specialized Register (11 January 2011), CENTRAL (2010, Issue 4), MEDLINE (January 1966 to January 2011) and EMBASE (January 1980 to January 2011). SELECTION CRITERIA: All randomised and quasi-randomised controlled studies of aerobic exercise training in people of all ages with McArdle disease. DATA COLLECTION AND ANALYSIS: Two authors identified possible studies for inclusion and assessed their methodological quality. Had more than one study of sufficient methodological quality been identified we would have undertaken a meta-analysis. MAIN
resultsThere were no randomised or quasi-randomised controlled trials of aerobic training in people with McArdle disease. However, three open studies using small numbers of participants provided some evidence that aerobic training improves fitness without adverse events in people with McArdle disease. AUTHORS'
conclusionsEvidence from non-randomised studies using small numbers of patients suggest that it would be safe and worthwhile for larger controlled trials of aerobic training to be undertaken in people with McArdle disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.