ReviewCurrent hypertension reports2012
Mendelian randomization: application to cardiovascular disease.
Review in Current hypertension reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adiposity as a cause of cardiovascular disease: a Mendelian randomization study.International journal of epidemiology · 2015Pooled it
- Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study.BMC medicine · 2018Trial
- Mendelian randomization analysis of the causal relationship between immune cells and keloid.Dermatology reports · 2025Article
- Causal role of 731 immune cells in diabetic nephropathy: a bi-directional two-sample Mendelian randomization study.International urology and nephrology · 2025Article
- Assessing the Causal Relationship Between Various Immune Cells and Attention Deficit Hyperactivity Disorder: Mendelian Randomization Study.Brain and behavior · 2025Article
- Investigation of causal associations between cerebral cortical structure and Barrett's esophagus: insights from Mendelian randomization and meta-analysis.Journal of thoracic disease · 2024Article
- Inflammatory cytokines and their potential role in kidney stone disease: a Mendelian randomization study.International urology and nephrology · 2024Article
- The Application of Mendelian Randomization in Cardiovascular Disease Risk Prediction: Current Status and Future Prospects.Reviews in cardiovascular medicine · 2024Review
- The immune factors have complex causal regulation effects on kidney stone disease: a mendelian randomization study.BMC immunology · 2024Article
- An exploration of the causal relationship between 731 immunophenotypes and osteoporosis: a bidirectional Mendelian randomized study.Frontiers in endocrinology · 2024Article
- A Mendelian analysis of the relationships between immune cells and breast cancer.Frontiers in oncology · 2024Article
- Assessment of the relationship between gut microbiota and bone mineral density: a two-sample Mendelian randomization study.Frontiers in microbiology · 2024Article
- Causal role of immune cells in hypertension: a bidirectional Mendelian randomization study.Frontiers in cardiovascular medicine · 2024Article
- Causal relationship between immune cells and hepatocellular carcinoma: a Mendelian randomisation study.Journal of Cancer · 2024Article
- Causal role of immune cells in schizophrenia: Mendelian randomization (MR) study.BMC psychiatry · 2023Article
- Causal association of immune cells and polycystic ovarian syndrome: a Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Cigarette smoking, coffee consumption, alcohol intake, and clozapine metabolism: A Mendelian randomization study.Frontiers in psychiatry · 2022Article
- Using genetics to decipher the link between type 2 diabetes and cancer: shared aetiology or downstream consequence?Diabetologia · 2020Review
- Causal Inference in Cancer Epidemiology: What Is the Role of Mendelian Randomization?Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Review
- MELODI: Mining Enriched Literature Objects to Derive Intermediates.International journal of epidemiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
In the absence of an ethical, practical, and economical randomized trial, the epidemiologist is left to explore other methods in efforts to assert causality. An approach based on genotypic variation has the potential to mitigate against some of the problems found within conventional observational studies. Genetic variations associated with risk factors of interest at the population level can be used as proxy measures for these risk factors and to generate estimates of causal effect. The potential and the possible limitations of this approach within the cardiovascular field are presented in this review.
Indexed as
Identifiers
22161218What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.