ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2012
Hypermethylation of Sox17 gene is useful as a molecular diagnostic application in early gastric cancer.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
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- Epigenetic Regulation in Oral Squamous Cell Carcinoma Microenvironment: A Comprehensive Review.Cancers · 2023Review
- PSRC1 Regulated by DNA Methylation Is a Novel Target for LGG Immunotherapy.Journal of molecular neuroscience : MN · 2023Article
- An overview of DNA methylation markers for early detection of gastric cancer: current status, challenges, and prospects.Frontiers in genetics · 2023Review
- Small extracellular vesicles in cancer.Bioactive materials · 2021Review
- A research of STEAP1 regulated gastric cancer cell proliferation, migration and invasion in vitro and in vivos.Journal of cellular and molecular medicine · 2020Article
- Review
- Hypermethylated promoters of tumor suppressor genes were identified in Crohn's disease patients.Intestinal research · 2020Article
- Aberrantly hypermethylated tumor suppressor genes were identified in oral squamous cell carcinoma (OSCC).Clinical epigenetics · 2019Article
- Transcriptomics analysis reveals new insights in E171-induced molecular alterations in a mouse model of colon cancer.Scientific reports · 2018Article
- Early detection of gastric cancer using global, genome-wide and IRF4, ELMO1, CLIP4 and MSC DNA methylation in endoscopic biopsies.Oncotarget · 2017Article
- WWC3 downregulation correlates with poor prognosis and inhibition of Hippo signaling in human gastric cancer.OncoTargets and therapy · 2017Article
- Tbx3 overexpression in human gastric cancer is correlated with advanced tumor stage and nodal status and promotes cancer cell growth and invasion.Virchows Archiv : an international journal of pathology · 2016Article
- Pathogenesis and risk factors for gastric cancer after Helicobacter pylori eradication.World journal of gastrointestinal oncology · 2016Review
- Analysis of Helicobacter pylori genotypes in clinical gastric wash samples.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- BARHL2 Methylation Using Gastric Wash DNA or Gastric Juice Exosomal DNA is a Useful Marker For Early Detection of Gastric Cancer in an H. pylori-Independent Manner.Clinical and translational gastroenterology · 2016Article
- Overexpression of SPAG9 in human gastric cancer is correlated with poor prognosis.Virchows Archiv : an international journal of pathology · 2015Article
- Decreased expression of SOX17 is associated with tumor progression and poor prognosis in breast cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- TRIM24 is upregulated in human gastric cancer and promotes gastric cancer cell growth and chemoresistance.Virchows Archiv : an international journal of pathology · 2015Article
- Biomarkers for gastric cancer: Progression in early diagnosis and prognosis (Review).Oncology letters · 2015Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although minimal invasive treatment is widely accepted in the early stages of gastric cancer (GCa), we still do not have any appropriate risk markers to detect residual neoplasia and the potential for recurrence. We previously reported that aberrant DNA methylation is an early and frequent process in gastric carcinogenesis and could be useful for the detection of gastric neoplasia. Our goal is to find and identify some candidate genes, using genome-wide DNA methylation analysis, as a treatment marker for early gastric cancer (EGC). We performed methylated CpG island amplification microarray analysis using 12 gastric washes (six each of pre- and post-endoscopic treatment in each of the same patients). We finally focused on Sox17 gene. We examined the DNA methylation status of Sox17 in a validation set consisting of 128 wash samples (pre, 64; post, 64) at EGC. We next carried out functional studies to identify Sox17. Sox17 showed significant differential methylation between pre- and post-treatments in EGC patients (Sox17, p < 0.0001). Moreover, treating GCa cells that lacked Sox17 expression with a methyltransferase inhibitor, 5-aza-2'-deoxycytidine, restored the gene's expression. Additionally, the introduction of exogenous Sox17 into silenced cells suppressed colony formation. Gastric wash-based DNA methylation analysis could be useful for early detection of recurrence following endoscopic resection in EGC patients. Our data suggest that the silencing of Sox17 occurs frequently in EGC and may play a key role in the development and progression of the disease.
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