Trial reportAmerican journal of respiratory and critical care medicine2012
Discordance among commercially available diagnostics for latent tuberculosis infection.
Trial report in American journal of respiratory and critical care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- C-Tb skin test to diagnose Mycobacterium tuberculosis infection in children and HIV-infected adults: A phase 3 trial.PloS one · 2018Trial
- Tuberculosis screening for patients on biologic Medications: A Single-Center experience and Society guideline Review, Monroe County, New York, 2018-2021.Journal of clinical tuberculosis and other mycobacterial diseases · 2024Article
- Monocyte-to-lymphocyte ratio is significantly associated with positive QuantiFERON-TB Gold-In-Tube and adult survival: an observational study.Scientific reports · 2022Observational
- Screening for latent tuberculosis before starting TNF-alpha inhibitors in a population with high BCG vaccination rates.Rheumatology international · 2022Article
- The diagnosis of latent tuberculosis infection (LTBI): currently available tests, future developments, and perspectives to eliminate tuberculosis (TB).La Medicina del lavoro · 2020Review
- Interferon Gamma Release Assays in Patients with Respiratory Isolates of Non-Tuberculous Mycobacteria - a Preliminary Study.Polish journal of microbiology · 2019Article
- Solitary pulmonary caseating granulomas: A 5-year retrospective single-center analysis.Molecular and clinical oncology · 2017Article
- Article
- Tuberculosis Screening and Control in the US Military in War and Peace.American journal of public health · 2017Article
- Challenges in Obtaining Estimates of the Risk of Tuberculosis Infection During Overseas Deployment.The American journal of tropical medicine and hygiene · 2015Article
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- Article
- Article
- Tuberculin skin testing and treatment modulates interferon-gamma release assay results for latent tuberculosis in migrants.PloS one · 2014Article
- Diagnosis and treatment of latent tuberculosis infection: an update.Current respiratory care reports · 2013Article
- A new cytokine release assay: a simple approach to monitor the immune status of HIV-infected patients.Infection · 2013Article
- Dynamic QuantiFERON Response in Psoriasis Patients Taking Long-Term Biologic Therapy.Dermatology and therapy · 2013Article
- Test variability of the QuantiFERON-TB gold in-tube assay in clinical practice.American journal of respiratory and critical care medicine · 2013Article
- A cough conundrum in a patient with a previous history of BCG immunotherapy for bladder cancer.BMJ case reports · 2012Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
rationaleThere is uncertainty regarding how to interpret discordance between tests for latent tuberculosis infection.
objectivesThe objective of this study was to assess discordance between commercially available tests for latent tuberculosis in a low-prevalence population, including the impact of nontuberculous mycobacteria.
methodsThis was a cross-sectional comparison study among 2,017 military recruits at Fort Jackson, South Carolina, from April to June 2009. Several tests were performed simultaneously with a risk factor questionnaire, including (1) QuantiFERON-TB Gold In-Tube test, (2) T-SPOT.TB test, (3) tuberculin skin test, and (4) Battey skin test using purified protein derivative from the Battey bacillus. MEASUREMENTS AND MAIN
resultsIn this low-prevalence population, the specificities of the three commercially available diagnostic tests were not significantly different. Of the 88 subjects with a positive test, only 10 (11.4%) were positive to all three tests; 20 (22.7%) were positive to at least two tests. Bacille Calmette-Guérin vaccination, tuberculosis prevalence in country of birth, and Battey skin test reaction size were associated with tuberculin skin test-positive, IFN-γ release assay-negative test discordance. Increasing agreement between the three tests was associated with epidemiologic criteria indicating risk of infection and with quantitative test results.
conclusionsFor most positive results the three tests identified different people, suggesting that in low-prevalence populations most discordant results are caused by false-positives. False-positive tuberculin skin test reactions associated with reactivity to nontuberculous mycobacteria and bacille Calmette-Guérin vaccination may account for a proportion of test discordance observed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.