ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2012
Prevalence and distribution of Helicobacter pylori cagA and vacA genotypes in the Moroccan population with gastric disease.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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14 citing papers in PubMed, 33 citations in OpenAlex.
- Review
- Antimicrobial resistance and virulence patterns ofInfectious medicine · 2026Article
- Genotypic diversity of theJournal of medical microbiology · 2025Article
- Moroccan Children With Helicobacter pylori Infection: Demographics, Clinical Features, and Histological Findings.Cureus · 2023Article
- Is There a Real Relationship between the Presence ofInternational journal of microbiology · 2023Article
- The high sensitivity and specificity of rapid urease test in diagnosis ofIranian journal of microbiology · 2022Article
- The EPIYA-ABCC motif of Helicobacter pylori cagA gene and gastric carcinogenesis in Casablanca population.African health sciences · 2022Article
- Comparison of Drug Resistance of Helicobacter pylori Between Children and Adults in Jilin, China.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021Article
- Infections withWorld journal of gastroenterology · 2019Review
- Article
- A review of the infection-associated cancers in North African countries.Infectious agents and cancer · 2016Review
- Helicobacter pylori genotypes associated with gastric histo-pathological damages in a Moroccan population.PloS one · 2013Article
- Helicobacter pylori Infection in the general population: A Middle Eastern perspective.Caspian journal of internal medicine · 2013Review
- Review
Corrections and comments
- Erratum issuedBoukhris, S A [corrected to Alaoui Boukhris, S]
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori infection is the etiologic agent of various gastric pathologies. The severity of disease outcome has been attributed to some H. pylori genotypes, which varies geographically. In Morocco, there are no data regarding the pattern of H. pylori genotypes; therefore, this is the first prospective study conducted in our country to investigate the genotype profiles (vacA and cagA) of H. pylori in patients with gastric pain. Endoscopic biopsies were obtained in patients attending the gastroenterology department of the Hospital University Hassan II of Fez for gastric pain and were directly used for H. pylori detection and genotyping by polymerase chain reaction (PCR). The SPSS software program was used to study the genotype correlation to different clinical outcomes. A total of 429 patients were included in this study, with an infection rate of 69.9%. cagA was detected in 42.3% of cases. However, vacA genotyping reveal a large predominance of s2m2. Infection with multiple strains was detected in 10.8% of cases and incomplete vacA was observed in 31.5%. In Morocco, vacA s1m1 was significantly associated to peptic ulcer diseases, while s2m2 was associated to gastritis. Moroccan H. pylori vacA genotype profiles differ from the Latin American, European, and South African profiles, with more similarities to the North African profile. Because of the small number of cases with gastric cancer, no correlations with H. pylori have been studied, so, further studies will be required in order to highlight the effects of those genes on this disease.
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