ArticleProceedings of the National Academy of Sciences of the United States of America2011
Low-affinity cation transporter (OsLCT1) regulates cadmium transport into rice grains.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers.
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Who cites it
127 citing papers in PubMed.
- Article
- Distinct cadmium detoxicity response between rice cultivars carrying functional or loss-of-function OsHMA3 allele.Stress biology · 2026Article
- Integrative genomics resolves rice loci associated with acidic soil-related aluminum, cadmium, and manganese stress responses.Plant cell reports · 2026Article
- The Multidrug Resistance Protein OsMDR4 Is Involved in Cadmium Absorption in Rice (Plants (Basel, Switzerland) · 2026Article
- Molecular insights into cadmium transport and micronutrient crosstalk in rice: Towards minimizing grain Cd.Journal of integrative plant biology · 2026Review
- Advances in Molecular Mechanisms Underlying Cadmium Accumulation and Detoxification in Durum Wheat (International journal of molecular sciences · 2026Review
- Transcriptomic and Physiological Analyses Reveal Potential Regulatory Networks of Cadmium Stress Response Mediated by PSR1 inCurrent issues in molecular biology · 2026Article
- miR408-5p and miR408-3p cooperatively reduce cadmium uptake and accumulation in rice.PLoS biology · 2026Article
- Establishment of a Non-transgenic Iron-Biofortified Rice Line Using a Novel HRZ1 Mutation.Rice (New York, N.Y.) · 2026Article
- Polyploidy and zinc nanoparticles enhanced cadmium tolerance by regulating antioxidants and transport proteins.Plant cell reports · 2026Article
- Review
- A transposon insertion in the 5' UTR of OsPT1 reprograms its expression pattern and promotes cadmium accumulation in rice grains.Plant communications · 2026Article
- Spatiotemporal Transcriptome Profiling Reveals Nutrient Transport Dynamics in Rice Nodes and Roots During Reproductive Development.International journal of molecular sciences · 2025Article
- Cadmium Contamination in Asian Rice (Plants (Basel, Switzerland) · 2025Review
- Navigating the genetic basis of cadmium accumulation: a comprehensive analysis of low-cadmium accumulation rice.Molecular breeding : new strategies in plant improvement · 2025Article
- Interactions of Fe, Mn, Zn, and Cd in Soil-Rice Systems: Implications for Reducing Cd Accumulation in Rice.Toxics · 2025Article
- Geochemical Speciation, Uptake, and Transportation Mechanisms of Arsenic, Cadmium, and Lead in Soil-Rice Systems: Additional Aspects and Challenges.Antioxidants (Basel, Switzerland) · 2025Review
- A Review of Reducing Cadmium Pollution in the Rice-Soil System in China.Foods (Basel, Switzerland) · 2025Review
- Engineering of nicotianamine synthesis enhances cadmium mobility in plants and results in higher seed cadmium concentrations.The Plant journal : for cell and molecular biology · 2025Article
- Defense guard: strategies of plants in the fight against Cadmium stress.Advanced biotechnology · 2024Review
67 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Accumulation of cadmium (Cd) in rice (Oryza sativa L.) grains poses a potential health problem, especially in Asia. Most Cd in rice grains accumulates through phloem transport, but the molecular mechanism of this transport has not been revealed. In this study, we identified a rice Cd transporter, OsLCT1, involved in Cd transport to the grains. OsLCT1-GFP was localized at the plasma membrane in plant cells, and OsLCT1 showed Cd efflux activity in yeast. In rice plants, strong OsLCT1 expression was observed in leaf blades and nodes during the reproductive stage. In the uppermost node, OsLCT1 transcripts were detected around large vascular bundles and in diffuse vascular bundles. RNAi-mediated knockdown of OsLCT1 did not affect xylem-mediated Cd transport but reduced phloem-mediated Cd transport. The knockdown plants of OsLCT1 accumulated approximately half as much Cd in the grains as did the control plants. The content of other metals in rice grains and plant growth were not negatively affected by OsLCT1 suppression. These results suggest that OsLCT1 functions at the nodes in Cd transport into grains and that in a standard japonica cultivar, the regulation of OsLCT1 enables the generation of "low-Cd rice" without negative effects on agronomical traits. These findings identify a transporter gene for phloem Cd transport in plants.
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