ArticleProceedings of the National Academy of Sciences of the United States of America2011
Dysregulation of Kruppel-like factor 4 during brain development leads to hydrocephalus in mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 78 citations in OpenAlex.
- KLF4 in Parkinson's Disease: Decoding the Molecular Puzzle of Neuroinflammation, Oxidative Stress, and Emerging Therapies.Current medical science · 2026Review
- Maternal Inflammation Alters Nuclear and Mitochondrial DNA Methylation Patterns in Neonatal Brain Monocytes.Cells · 2026Article
- Integrated analysis of porcine brain microRNA profiles following pediatric diffuse traumatic brain injury.Acta neuropathologica communications · 2026Article
- KLF7 orchestrates hippocampal development through neurogenesis and Draxin-mediated neuronal migration.Development (Cambridge, England) · 2025Article
- The human intelligence evolved from proximalQuantitative biology (Beijing, China) · 2025Article
- The KLF4/Galectin-3 cascade is a key determinant of tubular cell death and acute kidney injury.International journal of biological sciences · 2025Article
- Implications of Krüppel-like factor signaling in neuroinflammation for neurodegenerative diseases.American journal of translational research · 2025Review
- Therapeutic Targeting of Krüppel-Like Factor 4 and Its Pharmacological Potential in Parkinson's Disease: a Comprehensive Review.Molecular neurobiology · 2024Review
- Investigating Neuron Degeneration in Huntington's Disease Using RNA-Seq Based Transcriptome Study.Genes · 2023Article
- Krüppel-like factor 7 deficiency disrupts corpus callosum development and neuronal migration in the developing mouse cerebral cortex.Brain pathology (Zurich, Switzerland) · 2023Article
- Impaired ATF3 signaling involves SNAP25 in SOD1 mutant ALS patients.Scientific reports · 2023Article
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- Structural variation and eQTL analysis in two experimental populations of chickens divergently selected for feather-pecking behavior.Neurogenetics · 2023Article
- Methylation Profiling of Specific Genes in Ependymomas.Turk patoloji dergisi · 2022Article
- KLF4 Alleviates Hypertrophic Scar Fibrosis by Directly Activating BMP4 Transcription.International journal of biological sciences · 2022Article
- Altered hypothalamic DNA methylation and stress-induced hyperactivity following early life stress.Epigenetics & chromatin · 2021Article
- Generation of High-Yield, Functional Oligodendrocytes from a c-International journal of molecular sciences · 2021Article
- Sevoflurane Inhibits Traumatic Brain Injury-Induced Neuron ApoptosisFrontiers in cell and developmental biology · 2021Article
- Leptin stimulates synaptogenesis in hippocampal neurons via KLF4 and SOCS3 inhibition of STAT3 signaling.Molecular and cellular neurosciences · 2020Article
- Core regulatory circuitries in defining cancer cell identity across the malignant spectrum.Open biology · 2020Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Kruppel-like factor 4 (KLF4) is involved in self-renewal of embryonic stem cells and reprogramming of somatic cells to pluripotency. However, its role in lineage-committed stem cells remains largely unknown. Here, we show that KLF4 is expressed in neural stem cells (NSCs) and is down-regulated during neuronal differentiation. Unexpectedly, enhanced expression of KLF4 reduces self-renewal of cultured NSCs and inhibits proliferation of subventricular neural precursors in transgenic mice. Mice with increased KLF4 in NSCs and NSCs-derived ependymal cells developed hydrocephalus-like characteristics, including enlarged ventricles, thinned cortex, agenesis of the corpus callosum, and significantly reduced subcommissural organ. These characteristics were accompanied by elevation of GFAP expression and astrocyte hypertrophy. The ventricular cilia, vital for cerebrospinal fluid flow, are also disrupted in the mutant mice. These results indicate that down-regulation of KLF4 is critical for neural development and its dysregulation may lead to hydrocephalus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.