Trial reportJournal of cancer survivorship : research and practice2012
Health-related quality of life and biomarkers in breast cancer survivors participating in tai chi chuan.
Trial report in Journal of cancer survivorship : research and practice, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 26 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 26 syntheses or guidelines pooled it, 140 citations in OpenAlex.
- Effects of different mind-body exercises on quality of life and cancer-related fatigue in breast cancer survivors: a systematic review and network meta-analysis.Journal of cancer survivorship : research and practice · 2026Pooled it
- Comparative efficacy of different exercise interventions for cancer-related fatigue, health-related quality of life, anxiety and depression symptoms in cancer survivors: a systematic review and network meta-analysis.BMC public health · 2026Pooled it
- Performance of Tai Chi Chuan and NF-κB-driven proinflammatory gene expression (IL-6, IL-1β, TNF-α) in adult chronic disease patients: a systematic review and meta-analysis of randomized controlled trials.Frontiers in immunology · 2026Pooled it
- Effects of different exercise interventions on quality of life in breast cancer survivors after treatment: a systematic review and network meta-analysis.Frontiers in oncology · 2026Pooled it
- Effects and exercise-prescription moderators of Tai Chi on cardiometabolic risk factors in middle-aged and older women: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2026Pooled it
- Pooled it
- Effectiveness of qigong and Tai Chi for quality of life in patients with cancer: an umbrella review and meta-analysis.BMC complementary medicine and therapies · 2025Pooled it
- The impact of mind-body exercise on female breast cancer patients-a systematic review and meta-analysis of randomized controlled trials.Frontiers in public health · 2025Pooled it
- Effects of Tai Chi Chuan training on the QoL and psychological well-being in female patients with breast cancer: a systematic review of randomized controlled trials.Frontiers in oncology · 2023Pooled it
- Effects of exercise on inflammatory factors and IGF system in breast cancer survivors: a meta-analysis.BMC women's health · 2022Pooled it
- Effects of physical exercise on body fat and laboratory biomarkers in cancer patients: a meta-analysis of 35 randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Pooled it
- Tai Chi for cancer survivors: A systematic review toward consensus-based guidelines.Cancer medicine · 2021Pooled it
- The Effects of Martial Arts on Cancer-Related Fatigue and Quality of Life in Cancer Patients: An Up-to-Date Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.International journal of environmental research and public health · 2021Pooled it
- Current Evidence on Traditional Chinese Exercise for Cancers: A Systematic Review of Randomized Controlled Trials.International journal of environmental research and public health · 2020Pooled it
- Effect of Tai Chi Chuan in Breast Cancer Patients: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2020Pooled it
- The effects of Tai Chi on quality of life of cancer survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Pooled it
- Ameliorative effects of Tai Chi on cancer-related fatigue: a meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Pooled it
- Physical activity for women with breast cancer after adjuvant therapy.The Cochrane database of systematic reviews · 2018Pooled it
- Home-based multidimensional survivorship programmes for breast cancer survivors.The Cochrane database of systematic reviews · 2017Pooled it
- Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment.CA: a cancer journal for clinicians · 2017Guideline
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
introductionBreast cancer survivors experience diminished health-related quality of life (HRQOL). We report on the influence of tai chi chuan exercise (TCC) on HRQOL and explore associations between changes in HRQOL and biomarkers.
methodsBreast cancer survivors (N = 21) were randomly assigned to TCC or standard support therapy (SST) for 12 weeks (three times/week; 60 min/session). Interleukin-6, interleukin-8 (IL-8), insulin-like growth factor-1 (IGF-1), insulin-like growth factor-binding protein (IBFBP)-1, IGFBP-3, glucose, insulin, and cortisol were measured pre- and postintervention. Overall HRQOL and subdomains were assessed at preintervention (T1), midintervention (T2) and postintervention (T3) and biomarkers at T1 and T3.
resultsThe TCC group improved in total HRQOL (T1-T2:CS = 8.54, P = 0.045), physical functioning (T1-T2:CS = 1.89, P = 0.030), physical role limitations (T1-T2 CS = 1.55, P = 0.023), social functioning (T1-T3:CS = 1.50, P = 0.020), and general mental health (T1-T2:CS = 2.67, P = 0.014; T1-T3:CS = 2.44, P = 0.019). The SST improved in social functioning (T1-T2:CS = 0.64, P = 0.043) and vitality (T1-T2:CS = 0.90, P = 0.01). There were relationships between changes in IGF-1 and overall HRQOL (r = -0.56; P < 0.05), physical role limitation (r = -0.68; P < 0.05), and social functioning (r = -0.56; P < 0.05). IGFBP-1 changes were associated with physical role limitations changes (r = 0.60; P < 0.05). IGFBP-3 changes were associated with physical functioning changes (r = 0.46; P ≤ 0.05). Cortisol changes were associated with changes in physical role limitations (r = 0.74; P < 0.05) and health perceptions (r = 0.46; P < 0.05). Glucose changes were associated with emotional role limitation changes (r = -0.70; P < 0.001). IL-8 changes were associated with emotional role limitation changes (r = 0.59; P < 0.05). DISCUSSION/
conclusionsTCC may improve HRQOL by regulating inflammatory responses and other biomarkers associated with side effects from cancer and its treatments. IMPLICATIONS FOR CANCER SURVIVORS: TCC may be an intervention capable of improving HRQOL in breast cancer survivors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.