ArticleJournal of neuro-oncology2012
Β-elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells.
Article in Journal of neuro-oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- GPR55 and PINK1 as emerging therapeutic targets in Glioma: insights into their modulation by phytochemicals and plant extracts.Frontiers in pharmacology · 2026Review
- Mechanistic insights into the therapeutic potential of β-elemene on glioma and other central nervous system diseases.Medical oncology (Northwood, London, England) · 2025Review
- β-elemene combined with temozolomide in treatment of brain glioma.Biochemistry and biophysics reports · 2021Article
- Anti-Tumor Drug Discovery Based on Natural Product β-Elemene: Anti-Tumor Mechanisms and Structural Modification.Molecules (Basel, Switzerland) · 2021Review
- Chemical Characteristics and Anticancer Activity of Essential Oil fromMolecules (Basel, Switzerland) · 2020Article
- The Use of ß-Elemene to Enhance Radio Sensitization of A375 Human Melanoma Cells.Cell journal · 2020Article
- Essential Oil fromMolecules (Basel, Switzerland) · 2019Article
- Therapeutic effects of β-elemene via attenuation of the Wnt/β-catenin signaling pathway in cervical cancer cells.Molecular medicine reports · 2018Article
- Antitumor Mechanisms of Curcumae Rhizoma Based on Network Pharmacology.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- β-Elemene Selectively Inhibits the Proliferation of Glioma Stem-Like Cells Through the Downregulation of Notch1.Stem cells translational medicine · 2017Article
- Demethylation effects of elemene on the GSTP1 gene in HCC cell line QGY7703.Oncology letters · 2016Article
- Two Traditional Chinese Medicines Curcumae Radix and Curcumae Rhizoma: An Ethnopharmacology, Phytochemistry, and Pharmacology Review.Evidence-based complementary and alternative medicine : eCAM · 2016Review
- β-Elemene treatment of glioblastoma: a single-center retrospective study.OncoTargets and therapy · 2016Article
- Reversion of malignant phenotypes of human glioblastoma cells by β-elemene through β-catenin-mediated regulation of stemness-, differentiation- and epithelial-to-mesenchymal transition-related molecules.Journal of translational medicine · 2015Article
- The cytotoxic effect of β-elemene against malignant glioma is enhanced by base-excision repair inhibitor methoxyamine.Journal of neuro-oncology · 2013Article
- Antiproliferative and apoptotic effects of β-elemene on human hepatoma HepG2 cells.Cancer cell international · 2013Article
- Article
- Chemistry and biological activities of terpenoids from copaiba (Copaifera spp.) oleoresins.Molecules (Basel, Switzerland) · 2012Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
β-Elemene, an active component of herb medicine Curcuma wenyujin, has been shown to antagonize glioblastoma cells by inducing apoptosis. However, how β-elemene induces apoptosis of these cells remains unclear. In this study, we report that β-elemene disrupted the formation of the Hsp90/Raf-1 complex, a key step in maintaining the conformation stability of Raf-1, and caused deactivation of Raf-1 and inhibition of the ERK pathway, thereby leading to apoptosis of glioblastoma cells. Specifically, treatment of glioblastoma cell lines with β-elemene attenuated phosphorylation of multiple members of the kinase families in the Ras/Raf/MEK/ERK cascade, including Raf-1 and ERK as well as downstream signaling targets such as Bcl-2. These results suggest that the Hsp90/Raf-1 complex could be a promising molecular target for new drug development for the treatment of glioblastoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.