ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2012
Health-related quality of life in high-grade glioma patients: a prospective single-center study.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Understanding the Trajectory of Depressive Symptoms in Newly Diagnosed High-Grade Glioma Patients-A Meta-Analysis.Psycho-oncology · 2025Pooled it
- Symptom management in adult brain tumours: A literature review.Nursing open · 2023Pooled it
- Sleep disturbance of adults with a brain tumor and their family caregivers: a systematic review.Neuro-oncology · 2017Pooled it
- Impact of neurosurgical enhanced recovery after surgery (ERAS) program on health-related quality of life in glioma patients: a secondary analysis of a randomized controlled trial.Journal of neuro-oncology · 2020Trial
- Trial
- Neurocognitive function and health-related quality of life among glioblastoma patients: A prospective study.Journal of public health in Africa · 2025Article
- Progression-free survival versus post-progression survival and overall survival in WHO grade 2 gliomas.Acta oncologica (Stockholm, Sweden) · 2024Observational
- Acceptability and feasibility of cognitive assessments with adults with primary brain cancer and brain metastasis: A systematic review.Neuro-oncology practice · 2023Review
- Sleep disturbance in adults with untreated primary brain tumors: prevalence and impact on quality of life.Sleep and biological rhythms · 2023Article
- Exploring the prevalence and burden of sleep disturbance in primary brain tumor patients.Neuro-oncology practice · 2022Article
- Factors associated with health-related quality of life (HRQoL) deterioration in glioma patients during the progression-free survival period.Neuro-oncology · 2022Article
- Depression and Quality of Life in Patients with Gliomas: A Narrative Review.Journal of clinical medicine · 2022Review
- Association of Zolpidem With Increased Mortality in Patients With Brain Cancer: A Retrospective Cohort Study Based on the National Health Insurance Service Database.Journal of clinical neurology (Seoul, Korea) · 2022Article
- Prevalence of sleep disturbances and their effects on quality of life in adults with untreated pituitary tumor and meningioma.Journal of neuro-oncology · 2021Article
- The vicious interplay between disrupted sleep and malignant brain tumors: a narrative review.Croatian medical journal · 2021Review
- Development of screening questions for doctor-patient consultation assessing the quality of life and psychosocial burden of glioma patients: an explorative study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- Presenting Psychiatric and Neurological Symptoms and Signs of Brain Tumors before Diagnosis: A Systematic Review.Brain sciences · 2021Review
- Perioperative fatigue in patients with diffuse glioma.Journal of neuro-oncology · 2020Article
- A systematic review of cognitive function in patients with glioblastoma undergoing surgery.Neuro-oncology practice · 2020Review
- Analysis of factors influencing the access to concomitant chemo-radiotherapy in elderly patients with high grade gliomas: role of MMSE, age and tumor volume.Journal of neuro-oncology · 2017Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn this single center study, we aimed to assess quality of life and cognitive and emotional distress in patients treated for high-grade glioma. METHODS AND MATERIALS: A hundred and eighteen patients with high-grade glioma were prospectively enrolled. We assessed HRQoL at baseline (after surgery before radiotherapy), at the end of radiotherapy and during follow-up (every 3 months for the first 2 years and every 6 months between 2 and 5 years) using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire 30 (EORTC-C30), Brain Cancer Module-20 (BN-20), Minimental State Examination (MMSE) and Hospital Anxiety and Depression Scale (HADS). Baseline scores, and first 18-month follow-up period scores were included to statistical analysis.
resultsSixty-five (55%) patients had progressive tumor. Global score, physical, role and emotional function, insomnia (p for each <0.001) and appetite loss (p: 0.008) scores of EORTC-C30 significantly related to disease progression. According to BN-20 seizure and leg weakness (p < 0.001), drowsiness and bladder control (p: 0.002), motor dysfunction (p: 0.001), future uncertainty (p: 0.04), visual disorder (p: 0.008) and communication deficit (p: 0.006) symptoms significantly related to disease progression. There were significant decrements in orientation, attention and calculation and language scores (p values were 0.017, 0.005 and 0.003, respectively) of MMSE. The baseline and follow-up anxiety and depression scores did not differ significantly.
conclusionWe conclude that there were many changes in patients with high-grade glioma during the course of the disease and most of them were related to disease progression.
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