ArticleJournal of neural transmission (Vienna, Austria : 1996)2012
Imipramine reverses depressive-like parameters in pneumococcal meningitis survivor rats.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Glucocorticoids and the Brain after Critical Illness.Endocrinology · 2021Review
- Depression-Like Adult Behaviors may be a Long-Term Result of Experimental Pneumococcal Meningitis in Wistar Rats Infants.Neurochemical research · 2016Article
- Association between Experimental Bacterial Meningitis and Periapical Lesion.Journal of clinical and diagnostic research : JCDR · 2015Article
- FAT/CD36: a major regulator of neuronal fatty acid sensing and energy homeostasis in rats and mice.Diabetes · 2013Article
- Synergistic effects of celecoxib and bupropion in a model of chronic inflammation-related depression in mice.PloS one · 2013Article
- Neurobiology of COVID-19: how can the virus affect the brain?Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pneumococcal meningitis is a severe infectious disease of the central nervous system, associated with acute inflammation and might cause damage to the host, such as deafness, blindness, seizure, and learning deficits. However, infectious diseases can play a significant role in the etiology of neuropsychiatric disturbances. In this context, we evaluated depressive-like parameters; corticosterone and ACTH levels in pneumococcal meningitis surviving rats. Wistar rats underwent a magna cistern tap receiving either 10 μL sterile saline or a Streptococcus pneumoniae suspension at the concentration of 5 × 10(9) cfu/mL. After 3 days of meningitis induction procedure, the animals were treated with imipramine at 10 mg/kg or saline for 14 days (3rd-17th day). The consumption of sweet food was measured for 7 days (10th-17th day). The meningitis group decreased the sucrose intake and increased the levels of corticosterone and ACTH levels in the serum and TNF-α in the cortex; however, the treatment with imipramine reverted the reduction of sweet food consumption, normalized hormonal levels and TNF-α in the cortex. Our results supported the hypothesis that the pneumococcal meningitis surviving rats showed depressive-like behavior and alterations in the hypothalamus-pituitary-adrenal axis.
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