ArticleMolecular biology reports2012
Identification of potential serum biomarkers for Wilms tumor after excluding confounding effects of common systemic inflammatory factors.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- The Role of Epigenetics in the Progression of Clear Cell Renal Cell Carcinoma and the Basis for Future Epigenetic Treatments.Cancers · 2021Review
- Skeletal Muscle Dysfunction and Exercise Intolerance in Children Treated with Haematopoietic Stem Cell Transplant-A Pilot Feasibility Study.International journal of environmental research and public health · 2019Article
- Identification of proteins associated with pediatric bilateral Wilms tumor.Oncology letters · 2016Article
- Diagnostic and prognostic significance of serum apolipoprotein C-I in triple-negative breast cancer based on mass spectrometry.Cancer biology & therapy · 2016Article
- Diagnostic and prognostic role of serum protein peak at 6449 m/z in gastric adenocarcinoma based on mass spectrometry.British journal of cancer · 2016Article
- Screening and identification of post-traumatic stress-related serum factors in children with Wilms' tumors.Oncology letters · 2016Article
- Screening and identification of apolipoprotein A-I as a potential hepatoblastoma biomarker in children, excluding inflammatory factors.Oncology letters · 2015Article
- Detection of Serum Protein Biomarkers for the Diagnosis and Staging of Hepatoblastoma.International journal of molecular sciences · 2015Article
- DNA methylation profiling reveals novel diagnostic biomarkers in renal cell carcinoma.BMC medicine · 2014Article
- Identification of apolipoprotein C-I as a potential Wilms' tumor marker after excluding inflammatory factors.International journal of molecular sciences · 2014Article
- Innovations in the management of Wilms' tumor.Therapeutic advances in urology · 2014Review
- Clinical significance of serum biomarkers in pediatric solid mediastinal and abdominal tumors.International journal of molecular sciences · 2012Review
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wilms tumor is the most common pediatric tumor of the kidney. Previous studies have identified several serum biomarkers for Wilms tumor; however, they lack sufficient specificity and may not adequately distinguish Wilms tumor from confounding conditions. To date, no specific protein biomarker has been confirmed for this pediatric tumor. To identify novel serum biomarkers for Wilms tumor, we used proteomic technologies to perform protein profiling of serum samples from pre-surgery and post-surgery patients with Wilms tumor and healthy controls. Some common systemic inflammatory factors were included to control for systemic inflammation. By comparing protein peaks among the three groups of sera, we identified two peaks (11,526 and 4,756 Da) showing significant differential expression not only between pre-surgery and control sera but also between pre-surgery and post-surgery sera. These two peaks were identified as serum amyloid A1 (SAA1) and apolipoprotein C-III (APO C-III). Western blot analysis confirmed that both proteins were expressed at higher levels in pre-surgery sera than in post-surgery and control sera. Using the method of leave-1-out for cross detection, we demonstrate that detection of these two candidate biomarkers had high sensitivity and specificity in discriminating pre-surgery sera from post-surgery and normal control sera. Taken together, these findings suggest that SAA1 and APO C-III are two potential biomarkers for Wilms tumor.
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