Trial reportJournal of neural transmission (Vienna, Austria : 1996)2012
Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect.
Trial report in Journal of neural transmission (Vienna, Austria : 1996), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- A systematic review of neuroimaging and acute cannabis exposure in age-of-risk for psychosis.Translational psychiatry · 2021Pooled it
- Structural and functional imaging studies in chronic cannabis users: a systematic review of adolescent and adult findings.PloS one · 2013Pooled it
- Effect of Δ9-Tetrahydrocannabinol on frontostriatal resting state functional connectivity and subjective euphoric response in healthy young adults.Drug and alcohol dependence · 2021Trial
- Dose-related effects of delta-9-THC on emotional responses to acute psychosocial stress.Drug and alcohol dependence · 2017Trial
- Cannabinoid Modulation of Frontolimbic Activation and Connectivity During Volitional Regulation of Negative Affect.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Cannabinoid modulation of prefrontal-limbic activation during fear extinction learning and recall in humans.Neurobiology of learning and memory · 2014Trial
- Cannabinoid facilitation of fear extinction memory recall in humans.Neuropharmacology · 2013Trial
- Effects of THC, CBD, and Their Combination on EEG Dynamics in Rats.Physiological research · 2026Article
- Randomized trial of delta-9-tetrahydrocannabinol (THC) versus placebo to augment the effects of prolonged exposure therapy on fear extinction learning in post-traumatic stress disorder: Study rationale and protocol.Contemporary clinical trials · 2026Article
- Cannabinoids, reward processing, and psychosis.Psychopharmacology · 2022Review
- Effects of Acute Drug Administration on Emotion: A Review of Pharmacological MRI Studies.Current addiction reports · 2021Article
- The endocannabinoid system in humans: significant associations between anandamide, brain function during reward feedback and a personality measure of reward dependence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Attenuated neural response to emotional cues in cocaine-dependence: a preliminary analysis of gender differences.The American journal of drug and alcohol abuse · 2016Article
- Effects of oxycodone on brain responses to emotional images.Psychopharmacology · 2014Article
- Cannabinoid modulation of fear extinction brain circuits: a novel target to advance anxiety treatment.Current pharmaceutical design · 2014Review
- Pharmacologic magnetic resonance imaging (phMRI): imaging drug action in the brain.NeuroImage · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Cannabinoids affect positive and negative affective experience and emotional perception, possibly by modulating limbic brain reactivity. In this double-blind crossover, placebo-controlled functional magnetic resonance imaging study in humans, an acute oral dose of ∆(9)-tetrahydrocannabinol (THC) attenuated subgenual anterior cingulate cortex (sgACC) reactivity during the induction of negative affect. This observation extends prior findings implicating a cortico-limbic, emotion-related central mechanism underlying cannabinoid function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.