ArticleHuman genetics2012
Altered patterns of multiple recombinant events are associated with nondisjunction of chromosome 21.
Article in Human genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Maternal age as a driver of genome instability: mechanisms linking aneuploidy, mutagenesis and mitochondrial dysfunction.Archives of toxicology · 2026Review
- Telomere Biology, Erosion, and Age-Related Conditions: Insights from Down Syndrome and Other Telomere-Associated Disorders.Molecular neurobiology · 2025Review
- Article
- Suppression of meiotic crossovers in pericentromeric heterochromatin requires synaptonemal complex and meiotic recombination factors inbioRxiv : the preprint server for biology · 2024Article
- Article
- Centromere-Proximal Suppression of Meiotic Crossovers inbioRxiv : the preprint server for biology · 2023Article
- Trisomy 21 and Assisted Reproductive Technologies: A review.JBRA assisted reproduction · 2022Review
- Meiotic Cohesin and Variants Associated With Human Reproductive Aging and Disease.Frontiers in cell and developmental biology · 2021Review
- Crossover Position Drives Chromosome Remodeling for Accurate Meiotic Chromosome Segregation.Current biology : CB · 2020Article
- A candidate gene analysis and GWAS for genes associated with maternal nondisjunction of chromosome 21.PLoS genetics · 2019Article
- Crossover Interference, Crossover Maturation, and Human Aneuploidy.BioEssays : news and reviews in molecular, cellular and developmental biology · 2019Review
- The roles of homologous recombination and the immune system in the genomic evolution of cancer.Journal of translational science · 2019Article
- Age-Related Loss of Cohesion: Causes and Effects.International journal of molecular sciences · 2017Review
- Article
- Insights into epigenetic landscape of recombination-free regions.Chromosoma · 2016Review
- Association between telomere length and chromosome 21 nondisjunction in the oocyte.Human genetics · 2015Article
- Oocyte development, meiosis and aneuploidy.Seminars in cell & developmental biology · 2015Review
- Meiosis and maternal aging: insights from aneuploid oocytes and trisomy births.Cold Spring Harbor perspectives in biology · 2015Review
- The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defects.Frontiers in genetics · 2015Review
- TroX: a new method to learn about the genesis of aneuploidy from trisomic products of conception.Bioinformatics (Oxford, England) · 2014Article
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Authors and funding
12 authors.
Funding
Abstract
We have previously examined characteristics of maternal chromosomes 21 that exhibited a single recombination on 21q and proposed that certain recombination configurations are risk factors for either meiosis I (MI) or meiosis II (MII) nondisjunction. The primary goal of this analysis was to examine characteristics of maternal chromosomes 21 that exhibited multiple recombinant events on 21q to determine whether additional risk factors or mechanisms are suggested. In order to identify the origin (maternal or paternal) and stage (MI or MII) of the meiotic errors, as well as placement of recombination, we genotyped over 1,500 SNPs on 21q. Our analyses included 785 maternal MI errors, 87 of which exhibited two recombinations on 21q, and 283 maternal MII errors, 81 of which exhibited two recombinations on 21q. Among MI cases, the average location of the distal recombination was proximal to that of normally segregating chromosomes 21 (35.28 vs. 38.86 Mb), a different pattern than that seen for single events and one that suggests an association with genomic features. For MII errors, the most proximal recombination was closer to the centromere than that on normally segregating chromosomes 21 and this proximity was associated with increasing maternal age. This pattern is same as that seen among MII errors that exhibit only one recombination. These findings are important as they help us better understand mechanisms that may underlie both age-related and nonage-related meiotic chromosome mal-segregation.
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