ArticleMarine biotechnology (New York, N.Y.)2012
Identification of a Δ5-like fatty acyl desaturase from the cephalopod Octopus vulgaris (Cuvier 1797) involved in the biosynthesis of essential fatty acids.
Article in Marine biotechnology (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 83 citations in OpenAlex.
- Functional Characterization of Fad Genes from Two Chemosymbiotic Bivalves Inhabiting the Haima Cold Seep.Genes · 2026Article
- Genetic Resources for Research on the Regulatory Mechanism of ω-3 Fatty Acids in Oysters.Scientific data · 2025Article
- Genetic Variants Affecting FADS2 Enzyme Dynamics and Gene Expression in Cogenetic Oysters with Different PUFA Levels Provide New Tools to Improve Unsaturated Fatty Acids.International journal of molecular sciences · 2024Article
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- A complete enzymatic capacity for biosynthesis of docosahexaenoic acid (DHA, 22 : 6n-3) exists in the marine Harpacticoida copepodOpen biology · 2021Article
- Fatty Acids of Marine Mollusks: Impact of Diet, Bacterial Symbiosis and Biosynthetic Potential.Biomolecules · 2019Review
- De novo transcriptomic analysis of gonad of Strongylocentrotus nudus and gene discovery for biosynthesis of polyunsaturated fatty acids.Genes & genomics · 2019Article
- Insights into the phylogenetic and molecular evolutionary histories ofEcology and evolution · 2018Article
- Transcriptome analysis of gene expression patterns during embryonic development in golden cuttlefish (Sepia esculenta).Genes & genomics · 2018Article
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- Dietary Effect on the Proteome of the Common Octopus (Frontiers in physiology · 2017Article
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- Evolutionary functional elaboration of the Elovl2/5 gene family in chordates.Scientific reports · 2016Article
- Essential Fatty Acid Assimilation and Synthesis in Larvae of the Bivalve Crassostrea gigas.Lipids · 2015Article
- Comparative Analysis and Distribution of Omega-3 lcPUFA Biosynthesis Genes in Marine Molluscs.PloS one · 2015Article
- Functional characterization of a Δ5-like fatty acyl desaturase and its expression during early embryogenesis in the noble scallop Chlamys nobilis Reeve.Molecular biology reports · 2014Article
- Lipids and fatty acids of nudibranch mollusks: potential sources of bioactive compounds.Marine drugs · 2014Article
- Biosynthesis of polyunsaturated fatty acids in marine invertebrates: recent advances in molecular mechanisms.Marine drugs · 2013Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-chain polyunsaturated fatty acids (LC-PUFA) have been identified as essential compounds for common octopus (Octopus vulgaris), but precise dietary requirements have not been determined due, in part, to the inherent difficulties of performing feeding trials on paralarvae. Our objective is to establish the essential fatty acid (EFA) requirements for paralarval stages of the common octopus through characterisation of the enzymes of endogenous LC-PUFA biosynthetic pathways. In this study, we isolated a cDNA with high homology to fatty acyl desaturases (Fad). Functional characterisation in recombinant yeast showed that the octopus Fad exhibited Δ5-desaturation activity towards saturated and polyunsaturated fatty acyl substrates. Thus, it efficiently converted the yeast's endogenous 16:0 and 18:0 to 16:1n-11 and 18:1n-13, respectively, and desaturated exogenously added PUFA substrates 20:4n-3 and 20:3n-6 to 20:5n-3 (EPA) and 20:4n-6 (ARA), respectively. Although the Δ5 Fad enables common octopus to produce EPA and ARA, the low availability of its adequate substrates 20:4n-3 and 20:3n-6, either in the diet or by limited endogenous synthesis from C(18) PUFA, might indicate that EPA and ARA are indeed EFA for this species. Interestingly, the octopus Δ5 Fad can also participate in the biosynthesis of non-methylene-interrupted FA, PUFA that are generally uncommon in vertebrates but have been found previously in marine invertebrates, including molluscs, and now also confirmed to be present in specific tissues of common octopus.
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