ReviewPediatric nephrology (Berlin, Germany)2012
Can vitamin D slow down the progression of chronic kidney disease?
Review in Pediatric nephrology (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Cardiometabolic factors and vitamin D deficiency in pediatric patients with chronic kidney disease.Frontiers in nutrition · 2024Article
- Association between dietary inflammation index and albuminuria: results from the National Health and Nutrition Examination Survey.Frontiers in nutrition · 2024Article
- The Impact of Serum Levels of Vitamin D3 and Its Metabolites on the Prognosis and Disease Severity of COVID-19.Nutrients · 2022Article
- Hypervitaminosis D and nephrocalcinosis: too much of a good thing?Pediatric nephrology (Berlin, Germany) · 2022Article
- Acute kidney injury in children with chronic kidney disease is associated with faster decline in kidney function.Pediatric nephrology (Berlin, Germany) · 2021Article
- Association of vitamin D with the modulation of the disease severity in COVID-19.Virus research · 2020Article
- Immune Dysfunction in Uremia 2020.Toxins · 2020Review
- The Relationship Between Vitamin D Deficiency and Glycated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Ultraviolet B Exposure Inhibits Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice by Expanding CD4Journal of the American Heart Association · 2017Article
- Design and implementation of a custom next generation sequencing panel for selected vitamin D associated genes.BMC research notes · 2017Article
- Oral paricalcitol: expanding therapeutic options for pediatric chronic kidney disease patients.Pediatric nephrology (Berlin, Germany) · 2017Article
- Clinical practice recommendations for native vitamin D therapy in children with chronic kidney disease Stages 2-5 and on dialysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2017Article
- Matrix Metalloproteinase (MMP)-9 Levels in Children on Hemodialysis: Association with MMP-9 CInternational journal of biomedical science : IJBS · 2016Article
- Normal 25-Hydroxyvitamin D Levels Are Associated with Less Proteinuria and Attenuate Renal Failure Progression in Children with CKD.Journal of the American Society of Nephrology : JASN · 2016Article
- Serum vitamin D and parathyroid hormone profiles in patients with various stages of renal disease.The Australasian medical journal · 2015Article
- Is the renin-angiotensin system actually hypertensive?Pediatric nephrology (Berlin, Germany) · 2014Review
- Chronic kidney disease: a new look at pathogenetic mechanisms and treatment options.Pediatric nephrology (Berlin, Germany) · 2014Review
- An update on the pathomechanisms and future therapies of Alport syndrome.Pediatric nephrology (Berlin, Germany) · 2013Review
- Calcidiol deficiency in end-stage organ failure and after solid organ transplantation: status quo.Nutrients · 2013Review
- Cardiovascular risk assessment in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pharmacological blockade of the renin-angiotensin-aldosterone system (RAAS) is the cornerstone of renoprotective therapy, and the reduction of persistent RAAS activation is considered to be an important target in the treatment of chronic kidney disease (CKD). Vitamin D is a steroid hormone that controls a broad range of metabolic and cell regulatory functions. It acts as a transcription factor and can suppress the renin gene, thereby acting as a negative endocrine regulator of RAAS. RAAS activation can reduce renal Klotho expression, and the Klotho-fibroblast growth factor 23 interaction may further reduce the production of active vitamin D. Results from both clinical and experimental studies suggest that vitamin D therapy is associated with a reduction in blood pressure and left ventricular hypertrophy and improves cardiovascular outcomes. In addition, a reduction in angiotensin II through RAAS blockade may have anti-proteinuric and anti-fibrotic effects. Vitamin D has also been shown to modulate the immune system, regulate inflammatory responses, improve insulin sensitivity and reduce high-density lipoprotein cholesterol. Taken together, these pleiotropic effects of vitamin D may slow down the progression of CKD. In this review, we discuss the experimental and early clinical findings that suggest a renoprotective effect of vitamin D, thereby providing an additional rationale beyond mineral metabolism for the close monitoring of, and supplementation with vitamin D from the earliest stages of CKD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.