ArticlePflugers Archiv : European journal of physiology2012
Elasticity changes anti-correlate with NO production for human endothelial cells stimulated with TNF-α.
Article in Pflugers Archiv : European journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Mechanical Properties of Endothelial Cells: A Key to Physiology, Drug Testing and Nanostructure Interaction.Cells · 2025Review
- Rac1 regulates lipid droplets formation, nanomechanical, and nanostructural changes induced by TNF in vascular endothelium in the isolated murine aorta.Cellular and molecular life sciences : CMLS · 2022Article
- Endothelial glycocalyx shields the interaction of SARS-CoV-2 spike protein with ACE2 receptors.Scientific reports · 2021Article
- Lipid Droplets Formation Represents an Integral Component of Endothelial Inflammation Induced by LPS.Cells · 2021Article
- Biophysical nanocharacterization of liver sinusoidal endothelial cells through atomic force microscopy.Biophysical reviews · 2020Review
- Actin-spectrin scaffold supports open fenestrae in liver sinusoidal endothelial cells.Traffic (Copenhagen, Denmark) · 2019Article
- Immune Complexes Impaired Glomerular Endothelial Cell Functions in Lupus Nephritis.International journal of molecular sciences · 2019Article
- Degradation of Glycocalyx and Multiple Manifestations of Endothelial Dysfunction Coincide in the Early Phase of Endothelial Dysfunction Before Atherosclerotic Plaque Development in Apolipoprotein E/Low-Density Lipoprotein Receptor-Deficient Mice.Journal of the American Heart Association · 2019Article
- Endothelial Nanomechanics in the Context of Endothelial (Dys)function and Inflammation.Antioxidants & redox signaling · 2019Review
- AFM-based detection of glycocalyx degradation and endothelial stiffening in the db/db mouse model of diabetes.Scientific reports · 2017Article
- [Effect of dexmedetomidine postconditioning on myocardial ischemia-reperfusion injury and inflammatory response in diabetic rats].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- Unsaturated lipid bodies as a hallmark of inflammation studied by Raman 2D and 3D microscopy.Scientific reports · 2017Article
- An inverted dielectrophoretic device for analysis of attached single cell mechanics.Lab on a chip · 2016Article
- Feeling for Filaments: Quantification of the Cortical Actin Web in Live Vascular Endothelium.Biophysical journal · 2015Article
- TREK-1 Regulates Cytokine Secretion from Cultured Human Alveolar Epithelial Cells Independently of Cytoskeletal Rearrangements.PloS one · 2015Article
- Nanomechanics of vascular endothelium.Cell and tissue research · 2014Review
- TNF-α and IFN-γ promote lymphocyte adhesion to endothelial junctional regions facilitating transendothelial migration.Journal of leukocyte biology · 2014Article
- Stiffness memory of EA.hy926 endothelial cells in response to chronic hyperglycemia.Cardiovascular diabetology · 2013Article
- Nanomechanical sensing of the endothelial cell response to anti-inflammatory action of 1-methylnicotinamide chloride.International journal of nanomedicine · 2013Article
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Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor necrosis factor alpha (TNF-α) is a critical cytokine that is involved in systemic inflammatory response and contributes to the activation of the pro-inflammatory phenotype of the endothelium. In the present study, effects of TNF-α on morphology and elasticity of endothelium in relation to the production of NO and actin fiber reorganization were analyzed in human dermal microvascular endothelial cells. The cells were incubated in MCDB medium solution and stimulated with [Formula: see text] of TNF-α. Atomic force microscopy measurements have enabled characterization of cell morphology and elastic properties in physiological conditions. The spectrophotometric Griess method was applied to estimate nitric oxide (NO) production of the cells. We demonstrated that TNF-α-induced changes in elasticity of endothelium anti-correlate with NO production and are associated with the reorganization of actin cytoskeleton.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.