ArticleLangenbeck's archives of surgery2012
Alternating from subtotal thyroid resection to total thyroidectomy in the treatment of Graves' disease prevents recurrences but increases the frequency of permanent hypoparathyroidism.
Article in Langenbeck's archives of surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Huge variations in definition and reported incidence of postsurgical hypoparathyroidism: a systematic review.Endocrine · 2019Pooled it
- Diagnosis and treatment of hypoparathyroidism: a position statement from the Brazilian Society of Endocrinology and Metabolism.Archives of endocrinology and metabolism · 2018Guideline
- Thyroid surgery for Graves' disease and Graves' ophthalmopathy.The Cochrane database of systematic reviews · 2015Pooled it
- Lymph Node Dissection Morbidity in Thyroid Cancer: An Integrative Review.Sisli Etfal Hastanesi tip bulteni · 2021Review
- [Complications of lymph node dissection in thyroid cancer].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2020Review
- Incidence and risk factors for injuries to the recurrent laryngeal nerve during neck surgery in the moderate-volume setting.Langenbeck's archives of surgery · 2014Article
- Hypocalcaemia after total thyroidectomy for Graves' disease and for benign atoxic multinodular goitre.Langenbeck's archives of surgery · 2012Article
- [Intraoperative complications of neck surgery].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aims to compare the results of three different surgical techniques in the treatment of Graves' disease.
methodsAll patients operated on due to Graves' disease at a single institution between 1985 and 2009 were followed up for a median time of 152 months. The same endocrine surgeon operated altogether 265 patients; 111 with bilateral subtotal thyroid resection, 65 with lobectomy + unilateral subtotal resection (Dunhill's operation) and 99 with total thyroidectomy.
resultsRecurrence of thyreotoxicosis was seen in 11 (9.9%) patients operated on with bilateral thyroid resection, in two (3.1%) of those operated on with Dunhill's method and in none treated with total thyroidectomy. Permanent hypoparathyroidism was observed in 6% of the patients with total thyroidectomy, in 0.9% of those operated with bilateral subtotal resection and in none of the patients with Dunhill's procedure (p < 0.001). The frequency of permanent paresis of one recurrent laryngeal nerve was 2%, 0% and 1.5%, respectively, in the three different groups. At follow-up, thyroxine supplementation therapy was given to 81 (73%) of the patients treated with bilateral subtotal resection, to 58 (89%) of those treated with Dunhill's operation and to all of those treated with total thyroidectomy.
conclusionsIt is concluded that surgical treatment of Graves' disease with Dunhill's procedure, leaving a remnant of 1-2 g, seems to minimize the risks of both recurrences and permanent hypoparathyroidism.
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