ArticleActa neuropathologica2012
Myofibrillar disorganization characterizes myopathy of camptocormia in Parkinson's disease.
Article in Acta neuropathologica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Botulinum Toxin for Axial Postural Abnormalities in Parkinson's Disease: A Systematic Review.Toxins · 2024Pooled it
- The Study of Subthalamic Deep Brain Stimulation for Parkinson Disease-Associated Camptocormia.Medical science monitor : international medical journal of experimental and clinical research · 2020Trial
- LaminA/C-dependent cellular senescence signaling promotes skeletal muscle atrophy and abnormalities in Parkinson's disease.Cell death & disease · 2026Article
- Clinical Algorithm-Guided Approach to Botulinum Toxin Type A Treatment for Axial Postural Abnormalities in Parkinson's Disease.Movement disorders clinical practice · 2026Article
- Parkinson's disease-associated camptocormia: biopsy-confirmed focal myositis and treatment options.Journal of neurology · 2025Article
- Central Pathophysiology and Brain Network Changes Related to Camptocormia in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Camptocormia in Parkinson's disease: state of the art and future directions.Journal of neurology · 2025Review
- Alpha-Synuclein as a Potential Biomarker for Inclusion Body Myositis in Blood and Muscle.Neuropathology and applied neurobiology · 2025Article
- Pisa Syndrome Secondary to Drugs: A Scope Review.Geriatrics (Basel, Switzerland) · 2024Review
- Impaired skeletal muscle health in Parkinsonian syndromes: clinical implications, mechanisms and potential treatments.Journal of cachexia, sarcopenia and muscle · 2023Review
- Myofibrillar myopathy: a rare but important differential diagnosis of camptocormia in a patient with Parkinson's Disease.Neurological research and practice · 2023Article
- Characterizing Camptocormia in Parkinson's Disease Using Muscle Ultrasonography.Journal of Parkinson's disease · 2023Article
- Camptocormia in idiopathic normal pressure hydrocephalus: a case report.Acta neurologica Belgica · 2022Article
- Observational
- Brain and Muscle: How Central Nervous System Disorders Can Modify the Skeletal Muscle.Diagnostics (Basel, Switzerland) · 2020Review
- Pompe disease: what are we missing?Annals of translational medicine · 2019Review
- Body height loss characterizes camptocormia in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2018Article
- Managing Gait, Balance, and Posture in Parkinson's Disease.Current neurology and neuroscience reports · 2018Review
- Pathophysiological Concepts and Treatment of Camptocormia.Journal of Parkinson's disease · 2016Review
- Camptocormia in Parkinson's disease: definition, epidemiology, pathogenesis and treatment modalities.Journal of neurology, neurosurgery, and psychiatry · 2016Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Camptocormia is a highly disabling syndrome that occurs in various diseases but is particularly associated with Parkinson's disease (PD). Although first described nearly 200 years ago, the morphological changes associated with camptocormia are still under debate and the pathophysiology is unknown. We analyzed paraspinal muscle biopsies of 14 PD patients with camptocormia and compared the findings to sex-matched postmortem controls of comparable age to exclude biopsy site-specific changes. Camptocormia in PD showed a consistent lesion pattern composed of myopathic changes with type-1 fiber hypertrophy, loss of type-2 fibers, loss of oxidative enzyme activity, and acid phosphatase reactivity of lesions. Ultrastructurally, myofibrillar disorganization and Z-band streaming up to electron-dense patches/plaques were seen in the lesions. No aberrant protein aggregation, signs of myositis or mitochondriopathy were found, but the mitochondrial content of paraspinal muscles in patients and controls was markedly higher than known from limb biopsies. Additionally, we were able to demonstrate a link between the severity of the clinical syndrome and the degree of the myopathic changes. Because of the consistent lesion pattern, we propose criteria for the diagnosis of camptocormia in PD from muscle biopsies. The morphological changes show obvious parallels to the muscle pathology of experimental tenotomy reported in the 1970s, which depend on an intact innervation and do not occur after interruption of the myotactic reflexes. A dysregulation of the proprioception could be part of the pathogenesis of camptocormia in Parkinson's disease, particularly in view of the clinical symptoms of rigidity and loss of muscle strength.
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