ArticleAmerican journal of physiology. Lung cellular and molecular physiology2012
Intra-amniotic LPS and antenatal betamethasone: inflammation and maturation in preterm lamb lungs.
Article in American journal of physiology. Lung cellular and molecular physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 92 citations in OpenAlex.
- Glucocorticoids in pregnancy: a master-switch for fetal maturation.Endocrine reviews · 2026Review
- Effects of Common Therapies for Threatened Preterm Labor on the Placental Inflammatory Response.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Article
- Pathogenesis of bronchopulmonary dysplasia: an immunological perspective.Frontiers in immunology · 2026Review
- The epidemiology, pathology and pathogenesis of MS: Therapeutic implications.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Lipopolysaccharide Sensitizes Steroid-Induced Brain Injury in Neonatal Rat Pups.Mediators of inflammation · 2025Article
- Fetal origin of bronchopulmonary dysplasia: contribution of intrauterine inflammation.Molecular medicine (Cambridge, Mass.) · 2024Review
- Postnatal budesonide improved lung function in preterm lambs exposed to antenatal steroids and chorioamnionitis.Pediatric research · 2024Article
- Postnatal steroids as lung protective and anti-inflammatory in preterm lambs exposed to antenatal inflammation.Pediatric research · 2024Article
- Is there a role for early postnatal steroids in very preterm infants exposed to chorioamnionitis?Pediatric research · 2024Article
- Microbial signatures in amniotic fluid at preterm birth and association with bronchopulmonary dysplasia.Respiratory research · 2023Observational
- Understanding the role of placental pathophysiology in the development of bronchopulmonary dysplasia.American journal of physiology. Lung cellular and molecular physiology · 2022Review
- Techniques to evaluate surfactant activity for a personalized therapy of RDS neonates.Biomedical journal · 2021Review
- Betamethasone as a potential treatment for preterm birth associated with sterile intra-amniotic inflammation: a murine study.Journal of perinatal medicine · 2021Article
- Surfactant protein D and bronchopulmonary dysplasia: a new way to approach an old problem.Respiratory research · 2021Review
- Sequential Exposure to Antenatal Microbial Triggers Attenuates Alveolar Growth and Pulmonary Vascular Development and Impacts Pulmonary Epithelial Stem/Progenitor Cells.Frontiers in medicine · 2021Article
- Article
- Prenatal inflammation enhances antenatal corticosteroid-induced fetal lung maturation.JCI insight · 2020Article
- Bacterial Colonization within the First Six Weeks of Life and Pulmonary Outcome in Preterm Infants <1000 g.Journal of clinical medicine · 2020Article
- Immune System Remodelling by Prenatal Betamethasone: Effects on β-Cells and Type 1 Diabetes.Frontiers in endocrinology · 2020Review
- Fetal exposure to maternal inflammation interrupts murine intestinal development and increases susceptibility to neonatal intestinal injury.Disease models & mechanisms · 2019Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 3 countries.
Funding
Abstract
The proinflammatory stimulus of chorioamnionitis is commonly associated with preterm delivery. Women at risk of preterm delivery receive antenatal glucocorticoids to functionally mature the fetal lung. However, the effects of the combined exposures of chorioamnionitis and antenatal glucocorticoids on the fetus are poorly understood. Time-mated ewes with singleton fetuses received an intra-amniotic injection of lipopolysaccharide (LPS) either preceding or following maternal intramuscular betamethasone 7 or 14 days before delivery, and the fetuses were delivered at 120 days gestational age (GA) (term = 150 days GA). Gestation matched controls received intra-amniotic and maternal intramuscular saline. Compared with saline controls, intra-amniotic LPS increased inflammatory cells in the bronchoalveolar lavage and myeloperoxidase, Toll-like receptor 2 and 4 mRNA, PU.1, CD3, and Foxp3-positive cells in the fetal lung. LPS-induced lung maturation measured as increased airway surfactant and improved lung gas volumes. Intra-amniotic LPS-induced inflammation persisted until 14 days after exposure. Betamethasone treatment alone induced modest lung maturation but, when administered before intra-amniotic LPS, suppressed lung inflammation. Interestingly, betamethasone treatment after LPS did not counteract inflammation but enhanced lung maturation. We conclude that the order of exposures of intra-amniotic LPS or maternal betamethasone had large effects on fetal lung inflammation and maturation.
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Registered trials
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