ArticleAmerican journal of physiology. Lung cellular and molecular physiology2012
Pulmonary T cell activation in response to chronic particulate air pollution.
Article in American journal of physiology. Lung cellular and molecular physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Particulates induced lung inflammation and its consequences in the development of restrictive and obstructive lung diseases: a systematic review.Environmental science and pollution research international · 2021Pooled it
- Cardiopulmonary and Immune Effects of Environmental Particulate Exposures.Physiology (Bethesda, Md.) · 2026Review
- Immune impacts of fire smoke exposure.Nature medicine · 2025Article
- Ambient PMEpidemiology and infection · 2025Article
- Occupational exposure and its mechanistic link to allergic asthma and lung function decline; a data-driven approach coupled to mining of adverse outcome pathway signatures.Frontiers in toxicology · 2025Article
- Airborne culprits: A comprehensive review of PM, silica, and TCDD in autoimmune diseases.Journal of translational autoimmunity · 2024Review
- Air pollution exposure and cardiometabolic risk.The lancet. Diabetes & endocrinology · 2024Review
- Noise and Air Pollution as Risk Factors for Hypertension: Part II-Pathophysiologic Insight.Hypertension (Dallas, Tex. : 1979) · 2023Review
- Air pollution and respiratory infections: the past, present, and future.Toxicological sciences : an official journal of the Society of Toxicology · 2023Review
- Article
- Environmental risk factors and cardiovascular diseases: a comprehensive expert review.Cardiovascular research · 2022Article
- Long-term exposure to air pollution might decrease bone mineral density T-score and increase the prevalence of osteoporosis in Hubei province: evidence from China Osteoporosis Prevalence Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Lagged Effects of Exposure to Air Pollutants on the Risk of Pulmonary Tuberculosis in a Highly Polluted Region.International journal of environmental research and public health · 2022Article
- Current status and distribution of hip fractures among older adults in China.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- Environmental determinants of cardiovascular disease: lessons learned from air pollution.Nature reviews. Cardiology · 2020Review
- Oxidative stress pathways of air pollution mediated toxicity: Recent insights.Redox biology · 2020Review
- Outdoor Air Pollution and New-Onset Airway Disease. An Official American Thoracic Society Workshop Report.Annals of the American Thoracic Society · 2020Article
- Airborne Particulate Matter (PMInternational journal of molecular sciences · 2020Article
- Senescence in Pulmonary Fibrosis: Between Aging and Exposure.Frontiers in medicine · 2020Review
- House Dust Mite Allergy Under Changing Environments.Allergy, asthma & immunology research · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The purpose of this study was to investigate the effects of chronically inhaled particulate matter <2.5 μm (PM(2.5)) on inflammatory cell populations in the lung and systemic circulation. A prominent component of air pollution exposure is a systemic inflammatory response that may exaggerate chronic diseases such as atherosclerosis and insulin resistance. T cell response was measured in wild-type C57B/L6, Foxp3-green fluorescent protein (GFP) "knockin," and chemokine receptor 3 knockout (CXCR3(-/-)) mice following 24-28 wk of PM(2.5) or filtered air. Chronic PM(2.5) exposure resulted in increased CXCR3-expressing CD4(+) and CD8(+) T cells in the lungs, spleen, and blood with elevation in CD11c(+) macrophages in the lung and oxidized derivatives of 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine in wild-type mice. CXCR3 deficiency decreased T cells in the lung. GFP(+) regulatory T cells increased with PM(2.5) exposure in the spleen and blood of Foxp3-GFP mice but were present at very low levels in the lung irrespective of PM(2.5) exposure. Mixed lymphocyte cultures using primary, PM(2.5)-treated macrophages demonstrated enhanced T cell proliferation. Our experiments indicate that PM(2.5) potentiates a proinflammatory Th1 response involving increased homing of CXCR3(+) T effector cells to the lung and modulation of systemic T cell populations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.