Evidence map›Paper›PMID 22160303›Full record

ArticleMolecular medicine (Cambridge, Mass.)2012

Ghrelin attenuates brain injury after traumatic brain injury and uncontrolled hemorrhagic shock in rats.

Lei Qi, Xiaoxuan Cui, Weifeng Dong, Rafael Barrera, Jeffrey Nicastro, Gene F Coppa, Ping Wang, Rongqian Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

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  10. The role of regulatory necrosis in traumatic brain injury.Frontiers in molecular neuroscience · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Lei QiThe Feinstein Institute for Medical Research, Manhasset, New York, United States of America.
Xiaoxuan Cui
Weifeng Dong
Rafael Barrera
Jeffrey Nicastro
Gene F Coppa
Ping Wang
Rongqian Wu
North Shore University Hospital · USXi'an Jiaotong University · CN

Funding

Ghrelin and Traumatic Brain InjuryR21NS072608 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI WU, RONGQIAN · 2011 to 2012
$457k
NINDS NIH HHS R21 NS072608
6 · The paper itself

Abstract

Traumatic brain injury (TBI) and hemorrhagic shock often occur concomitantly due to multiple injuries. Gastrointestinal dysfunction occurs frequently in patients with TBI. However, whether alterations in the gastrointestinal system are involved in modulating neuronal damage and recovery after TBI is largely neglected. Ghrelin is a "gut-brain" hormone with multiple functions including antiinflammation and antiapoptosis. The purpose of this study was to determine whether ghrelin attenuates brain injury in a rat model of TBI and uncontrolled hemorrhage (UH). To study this, brain injury was induced by dropping a 450-g weight from 1.5 m onto a steel helmet attached to the skull of male adult rats. Immediately after TBI, a midline laparotomy was performed and both lumbar veins were isolated and severed at the junction with the vena cava. At 45 min after TBI/UH, ghrelin (4, 8 or 16 nmol/rat) or 1 mL normal saline (vehicle) was intravenously administered. Brain levels of TNF-α and IL-6, and cleaved PARP-1 levels in the cortex were measured at 4 h after TBI/UH. Beam balance test, forelimb placing test and hindlimb placing test were used to assess sensorimotor and reflex function. In additional groups of animals, ghrelin (16 nmol/rat) or vehicle was subcutaneously (s.c.) administered daily for 10 d after TBI/UH. The animals were monitored for 28 d to record body weight changes, neurological severity scale and survival. Our results showed that ghrelin downregulated brain levels of TNF-α and IL-6, reduced cortical levels of cleaved PARP-1, improved sensorimotor and reflex functions, and decreased mortality after TBI/UH. Thus, ghrelin has a great potential to be further developed as an effective resuscitation approach for the trauma victims with brain injury and severe blood loss.

Indexed as

AnimalsBlotting, WesternBrain Hemorrhage, TraumaticBrain InjuriesGhrelinImmunohistochemistryInterleukin-6MalePoly (ADP-Ribose) Polymerase-1Poly(ADP-ribose) PolymerasesRatsRats, Sprague-DawleyShock, HemorrhagicTumor Necrosis Factor-alphaGhrelinInterleukin-6Parp1 protein, ratPoly (ADP-Ribose) Polymerase-1Poly(ADP-ribose) PolymerasesTumor Necrosis Factor-alpha

Identifiers

PMID22160303
PMCPMC3320141
OpenAlexW1606398286

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.