ArticleIntensive care medicine2012
Discontinuation of prolonged infusions of dexmedetomidine in critically ill children with heart disease.
Article in Intensive care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Incidence of bradycardia in pediatric patients receiving dexmedetomidine anesthesia: a meta-analysis.International journal of clinical pharmacy · 2017Pooled it
- Population Pharmacokinetics of Dexmedetomidine in Infants.Journal of clinical pharmacology · 2017Trial
- Dexmedetomidine Use in Critically Ill Children With Acute Respiratory Failure.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2016Trial
- Guanfacine for the management of the behavioral manifestations of delirium in older hospitalized adults.The mental health clinician · 2025Article
- The Perioperative Use of Dexmedetomidine in Paediatric Patients.Children (Basel, Switzerland) · 2025Review
- Dexmedetomidine: Shifting Paradigms in Neonatal Sedation and Pain Control.Children (Basel, Switzerland) · 2025Review
- Differences in efficacy and safety of midazolam vs. dexmedetomidine in critically ill patients: A meta-analysis of randomized controlled trial.Experimental and therapeutic medicine · 2021Article
- Clonidine for the Treatment of Agitation After Dexmedetomidine Discontinuation in Pediatric Patients: A Retrospective Cohort Study.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021Article
- Effects of a Clonidine Taper on Dexmedetomidine Use and Withdrawal in Adult Critically Ill Patients-A Pilot Study.Critical care explorations · 2020Article
- The Impact of a Clonidine Transition Protocol on Dexmedetomidine Withdrawal in Critically Ill Pediatric Patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2020Article
- Incidence of Dexmedetomidine Withdrawal in Adult Critically Ill Patients: A Pilot Study.Critical care explorations · 2019Article
- Efficacy and Safety of Postoperative Dexmedetomidine Administration in Infants and Children Undergoing Cardiac Surgery: A Retrospective Cohort Study.Journal of pediatric intensive care · 2015Article
- Review
- Pediatric Withdrawal Identification and Management.Journal of pediatric intensive care · 2015Review
- Pain and Sedation Management in Mechanically Ventilated Children.Journal of pediatric intensive care · 2015Review
- Year in review in Intensive Care Medicine 2012: III. Noninvasive ventilation, monitoring and patient-ventilator interactions, acute respiratory distress syndrome, sedation, paediatrics and miscellanea.Intensive care medicine · 2013Review
- Safety and Effectiveness of Dexmedetomidine in the Pediatric Intensive Care Unit (SAD-PICU).The Canadian journal of hospital pharmacy · 2013Article
- Survey of the Current Use of Dexmedetomidine and Management of Withdrawal Symptoms in Critically Ill Children.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGArticle
- Prolonged Dexmedetomidine Infusion and Drug Withdrawal In Critically Ill Children.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGArticle
- Effects of Clonidine on Withdrawal From Long-term Dexmedetomidine in the Pediatric Patient.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo describe changes in hemodynamic variables, sedation, and pain score after discontinuation of prolonged infusions of dexmedetomidine in a pediatric population of critically ill cardiac patients.
methodsRetrospective case series of patients who received continuous infusions of dexmedetomidine for longer than 3 days in a pediatric cardiac intensive care unit from 2008 to 2010.
resultsSixty-two patients, age 5.2 months (range 0.3 months-17 years) and weight 5.1 kg (range 2.2-84 kg), were included. Thirty-nine patients (63%) were younger than 1 year of age. Median duration of dexmedetomidine infusion was 5.8 days (range 4-26 days) and median infusion dose was 0.71 μg/kg/h (range 0.2-2.1 μg/kg/h). Median weaning time and dose at discontinuation were 43 h (range 0-189 h) and 0.2 μg/kg/h (range 0.1-1.3 μg/kg/h). Tachycardia, transient hypertension and agitation were observed in 27, 35 and 27% of patients. Episodes of tachycardia were more frequent in children older than 1 year of age (61 vs. 8%, p < 0.001), patients who received dexmedetomidine for 4 days when compared to those who received 5 days or longer (48 vs. 17%, p = 0.011), and patients whose infusion was discontinued abruptly (42 vs. 14%, p = 0.045). Tachyarrhythmias were seen in nine patients (15%) after discontinuation of the dexmedetomidine infusion. Adequate sedation and analgesia scores at the moment of infusion discontinuation were seen in 90 and 88% of patients, respectively.
conclusionsOur study suggests that tachycardia, transient hypertension, and agitation are frequently observed in pediatric cardiac intensive care unit patients after discontinuing prolonged dexmedetomidine infusions.
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Registered trials
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