ArticleThe journal of nutrition, health & aging2011
Transitions in cognitive status in relation to frailty in older adults: a comparison of three frailty measures.
Article in The journal of nutrition, health & aging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- Efficacy and safety of pharmacotherapy for Alzheimer's disease and for behavioural and psychological symptoms of dementia in older patients with moderate and severe functional impairments: a systematic review of controlled trials.Alzheimer's research & therapy · 2021Pooled it
- Frailty syndrome and cognitive impairment in older adults: systematic review of the literature.Revista latino-americana de enfermagem · 2019Pooled it
- Psychometric properties of multicomponent tools designed to assess frailty in older adults: A systematic review.BMC geriatrics · 2016Pooled it
- Article
- Frailty is associated with the clinical expression of neuropsychological deficits in older adults.European journal of neurology · 2024Article
- Review
- Frailty among middle-aged and older women and men in India: findings from wave 1 of the longitudinal Ageing study in India.BMJ open · 2023Article
- The Longitudinal Association Between Frailty, Cognition, and Quality of Life in Older Europeans.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Inflammaging and Frailty in Immune-Mediated Rheumatic Diseases: How to Address and Score the Issue.Clinical reviews in allergy & immunology · 2023Review
- The concurrent impact of mild cognitive impairment and frailty syndrome in heart failure.Archives of medical science : AMS · 2023Article
- The role of vitamin D in the link between physical frailty and cognitive function: A mediation analysis in community-dwelling Chinese older adults.Frontiers in nutrition · 2022Article
- Frailty-a risk factor of global and domain-specific cognitive decline among a nationally representative sample of community-dwelling older adult U.S. Medicare beneficiaries.Age and ageing · 2021Article
- Physical Frailty Phenotype Criteria and Their Synergistic Association on Cognitive Functioning.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- The degree of frailty as a translational measure of health in aging.Nature aging · 2021Review
- Comparison of three frailty measures for 90-day outcomes of elderly patients undergoing elective abdominal surgery.ANZ journal of surgery · 2021Article
- Cumulative health deficits,Journal of neurology, neurosurgery, and psychiatry · 2021Article
- Geriatric Syndromes in People Living with HIV Associated with Ageing and Increasing Comorbidities: Implications for Neurocognitive Complications of HIV Infection.Current topics in behavioral neurosciences · 2021Article
- Review
- Trajectories of Frailty and Cognitive Decline Among Older Mexican Americans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Frailty syndrome in rheumatoid arthritis and symptomatic osteoarthritis: an emerging concept in rheumatology.Acta bio-medica : Atenei Parmensis · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesCognitive decline is related to frailty. Frailty can be operationalized in different ways, which have an unknown impact on the estimation of risk. Here, we compared 3 frailty measures in relation to cognitive changes and mortality in the Canadian Study of Health and Aging (CSHA).
designProspective population-based study, with 5 year follow up. PARTICIPANTS/
setting2,305 subjects aged 70+ years.
methodsFor each participant, cognitive status was measured by the errors in the Modified Mini-Mental State Examination (3MS) score. Three frailty measures were used: a Frailty Index based on the Comprehensive Geriatric Assessment (FI-CGA) evaluated from 47 potential deficits, a Clinical Frailty Score and the Fried frailty phenotype. Multivariate Poisson regression and multivariate logistic regression were used to examine the association between baseline cognitive errors and frailty and death, respectively, while controlling for possible confounders (age, sex, education, and baseline cognitive status).
resultsChanges in cognitive status were strongly associated with baseline cognition and frailty, however defined. In multivariate models adjusted for age, sex and education, each frailty measure was associated with cognitive decline and with mortality. The frailest people (from the highest FI-CGA tertile) rarely showed cognitive improvement or stabilization (1.5%, 95% CI=0.002%-2.8%) compared with non-frail people (from the lowest tertile of the FI-CGA), of whom 27.8% (95% CI=24.5%-31.1%) did not deteriorate.
conclusionsFrail elderly people have an increased risk of cognitive decline. All frailty measures allowed quantification of individual vulnerability and predict both cognitive changes and mortality.
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Registered trials
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