ArticleCellular and molecular life sciences : CMLS2012
Morphological and functional characterization of leech circulating blood cells: role in immunity and neural repair.
Article in Cellular and molecular life sciences : CMLS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Blood Relatives: Linking Evolutionary History and Conservation of Medicinal Leeches (Evolutionary applications · 2026Article
- Role of Antimicrobial Peptides in Immunity of Parasitic Leeches.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2023Article
- Zhilong Huoxue Tongyu Capsules' Effects on ischemic stroke: An assessment using fecal 16S rRNA gene sequencing and untargeted serum metabolomics.Frontiers in pharmacology · 2022Article
- A New Protocol of Computer-Assisted Image Analysis Highlights the Presence of Hemocytes in the Regenerating Cephalic Tentacles of AdultInternational journal of molecular sciences · 2021Article
- ALK4/5-dependent TGF-β signaling contributes to the crosstalk between neurons and microglia following axonal lesion.Scientific reports · 2019Article
- Reciprocal immune benefit based on complementary production of antibiotics by the leech Hirudo verbana and its gut symbiont Aeromonas veronii.Scientific reports · 2015Article
- Hm-MyD88 and Hm-SARM: two key regulators of the neuroimmune system and neural repair in the medicinal leech.Scientific reports · 2015Article
- Characterization and function of the first antibiotic isolated from a vent organism: the extremophile metazoan Alvinella pompejana.PloS one · 2014Article
- The leech nervous system: a valuable model to study the microglia involvement in regenerative processes.Clinical & developmental immunology · 2013Review
- Macin family of antimicrobial proteins combines antimicrobial and nerve repair activities.The Journal of biological chemistry · 2012Article
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Authors and funding
6 authors.
Funding
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Abstract
Unlike most invertebrates, annelids possess a closed vascular system distinct from the coelomic liquid. The morphology and the function of leech blood cells are reported here. We have demonstrated the presence of a unique cell type which participates in various immune processes. In contrast to the mammalian spinal cord, the leech CNS is able to regenerate and restore function after injury. The close contact of the blood with the nerve cord also led us to explore the participation of blood in neural repair. Our data evidenced that, in addition to exerting peripheral immune functions, leech blood optimizes CNS neural repair through the release of neurotrophic substances. Circulating blood cells also appeared able to infiltrate the injured CNS where, in conjunction with microglia, they limit the formation of a scar. In mammals, CNS injury leads to the generation of a glial scar that blocks the mechanism of regeneration by preventing axonal regrowth. The results presented here constitute the first description of neuroimmune functions of invertebrate blood cells. Understanding the basic function of the peripheral circulating cells and their interactions with lesioned CNS in the leech would allow us to acquire insights into the complexity of the neuroimmune response of the injured mammalian brain.
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