ArticleProceedings. Biological sciences2012
Selection for mitonuclear co-adaptation could favour the evolution of two sexes.
Article in Proceedings. Biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Paternal leakage of mitochondrial DNA is genetically controlled in Drosophila.G3 (Bethesda, Md.) · 2026Article
- Optimal Organelle Inheritance Strategies Under Different Changing Environments and Mutational Pressures.Genome biology and evolution · 2026Article
- Modes and mechanisms for the inheritance of mitochondria and plastids in pathogenic protists.PLoS pathogens · 2025Review
- Pervasive heteroplasmy in an invasive ambrosia beetle (Scolytinae) in southern California.Heredity · 2024Article
- Evolution and maintenance of mtDNA gene content across eukaryotes.The Biochemical journal · 2024Review
- Selectively advantageous instability in biotic and pre-biotic systems and implications for evolution and aging.Frontiers in aging · 2024Review
- Cellular and environmental dynamics influence species-specific extents of organelle gene retention.Proceedings. Biological sciences · 2023Article
- Inheritance through the cytoplasm.Heredity · 2022Review
- Sex-linked deubiquitinase establishes uniparental transmission of chloroplast DNA.Nature communications · 2022Article
- Fitness differences suppress the number of mating types in evolving isogamous species.Royal Society open science · 2020Article
- Evolving mtDNA populations within cells.Biochemical Society transactions · 2019Review
- Invasion and Extinction Dynamics of Mating Types Under Facultative Sexual Reproduction.Genetics · 2019Article
- Evolution of asymmetric gamete signaling and suppressed recombination at the mating type locus.eLife · 2019Article
- Selfish Mitonuclear Conflict.Current biology : CB · 2019Review
- Population genomics and geographical parthenogenesis in Japanese harvestmen (Opiliones, Sclerosomatidae,Ecology and evolution · 2018Article
- Article
- Sexual conflict explains the extraordinary diversity of mechanisms regulating mitochondrial inheritance.BMC biology · 2017Article
- Testing for the Occurrence of Selective Episodes During the Divergence of Otophysan Fishes: Insights from Mitogenomics.Journal of molecular evolution · 2017Article
- Uniparental Inheritance Promotes Adaptive Evolution in Cytoplasmic Genomes.Molecular biology and evolution · 2017Article
- Selection for Mitochondrial Quality Drives Evolution of the Germline.PLoS biology · 2016Article
Corrections and comments
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Mitochondria are descended from free-living bacteria that were engulfed by another cell between one and a half to two billion years ago. A redistribution of DNA led to most genetic information being lost or transferred to a large central genome in the nucleus, leaving a residual genome in each mitochondrion. Oxidative phosphorylation, the most critical function of mitochondria, depends on the functional compatibility of proteins encoded by both the nucleus and mitochondria. We investigate whether selection for adaptation between the nuclear and mitochondrial genomes (mitonuclear co-adaptation) could, in principle, have promoted uniparental inheritance of mitochondria and thereby the evolution of two mating types or sexes. Using a mathematical model, we explore the importance of the radical differences in ploidy levels, sexual and asexual modes of inheritance, and mutation rates of the nucleus and mitochondria. We show that the major features of mitochondrial inheritance, notably uniparental inheritance and bottlenecking, enhance the co-adaptation of mitochondrial and nuclear genes and therefore improve fitness. We conclude that, under a wide range of conditions, selection for mitonuclear co-adaptation favours the evolution of two distinct mating types or sexes in sexual species.
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