SynthesisHypertension (Dallas, Tex. : 1979)2012
Systematic review and meta-analysis of preterm birth and later systolic blood pressure.
Synthesis in Hypertension (Dallas, Tex. : 1979), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 233 papers, 14 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
233 citing papers in PubMed, 14 syntheses or guidelines pooled it, 526 citations in OpenAlex.
- Kidney health outcomes in children born very prematurely compared to full-term counterparts: a systematic review and meta-analysis.Pediatric nephrology (Berlin, Germany) · 2026Pooled it
- Neonatal Hair Cortisol and Birth Outcomes: An Empirical Study and Meta-Analysis.Psychosomatic medicine · 2024Pooled it
- Influence of Preterm Birth and Low Birthweight on Physical Fitness: A Systematic Review, Meta-Analysis, and Meta-Regression.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- Effects of size at birth on health, growth and developmental outcomes in children up to age 18: an umbrella review.Archives of disease in childhood · 2023Pooled it
- Association of the COVID-19 pandemic on stroke admissions and treatment globally: a systematic review.BMJ open · 2023Pooled it
- Maternal overnutrition elevates offspring's blood pressure-A systematic review and meta-analysis.Paediatric and perinatal epidemiology · 2022Pooled it
- The association between late preterm birth and cardiometabolic conditions across the life course: A systematic review and meta-analysis.Paediatric and perinatal epidemiology · 2022Pooled it
- The Long-Term Effect of Preterm Birth on Renal Function: A Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Risk factors during first 1,000 days of life for carotid intima-media thickness in infants, children, and adolescents: A systematic review with meta-analyses.PLoS medicine · 2020Pooled it
- Preterm birth and mortality in adulthood: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2020Pooled it
- Factors Predisposing to Hypertension in Subjects Formerly Born Preterm: Renal Impairment, Arterial Stiffness, Endothelial Dysfunction or Something Else?Current hypertension reviews · 2020Pooled it
- Sodium intake and blood pressure in children with clinical conditions: A systematic review with meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2019Pooled it
- A best-practice position statement on pregnancy after kidney transplantation: focusing on the unsolved questions. The Kidney and Pregnancy Study Group of the Italian Society of Nephrology.Journal of nephrology · 2018Guideline
- Monitoring postnatal growth of preterm infants: present and future.The American journal of clinical nutrition · 2016Pooled it
- Hydrocortisone administration in preterm infants is not associated with adverse cardiovascular outcomes in childhood.Pediatric research · 2026Trial
- Childhood outcomes after maternal antenatal sildenafil treatment for severe early-onset fetal growth restriction: a randomized trial (STRIDER NZAus).Journal of perinatology : official journal of the California Perinatal Association · 2024Trial
- Impact of maternal health on neonatal and long-term kidney outcomes.Pediatric nephrology (Berlin, Germany) · 2026Review
- Perinatal Factors Associated With Standardized Blood Pressure Percentiles for Children Aged 6 to 12 Years: The BOSHI Study.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- The Impact of Early-Life Growth on Long-Term Cardiometabolic and Neurocognitive Outcomes in High-Income Countries: A Neglected Public Health Problem.Nutrition reviews · 2026Review
- Bibliometric analysis of reviews of outcomes for adults with a complex perinatal history.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
173 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Lower birth weight because of fetal growth restriction is associated with higher blood pressure later in life, but the extent to which preterm birth (<37 completed weeks' gestation) or very low birth weight (<1500 g) predicts higher blood pressure is less clear. We performed a systematic review of 27 observational studies that compared the resting or ambulatory systolic blood pressure or diagnosis of hypertension among children, adolescents, and adults born preterm or very low birth weight with those born at term. We performed a meta-analysis with the subset of 10 studies that reported the resting systolic blood pressure difference in millimeters of mercury with 95% CIs or SEs. We assessed methodologic quality with a modified Newcastle-Ottawa Scale. The 10 studies were composed of 1342 preterm or very low birth weight and 1738 term participants from 8 countries. The mean gestational age at birth of the preterm participants was 30.2 weeks (range: 28.8-34.1 weeks), birth weight was 1280 g (range: 1098-1958 g), and age at systolic blood pressure measurement was 17.8 years (range: 6.3-22.4 years). Former preterm or very low birth weight infants had higher systolic blood pressure than term infants (pooled estimate: 2.5 mm Hg [95% CI: 1.7-3.3 mm Hg]). For the 5 highest quality studies, the systolic blood pressure difference was slightly greater, at 3.8 mm Hg (95% CI: 2.6-5.0 mm Hg). We conclude that infants who are born preterm or very low birth weight have modestly higher systolic blood pressure later in life and may be at increased risk for developing hypertension and its sequelae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.