Evidence map›Paper›PMID 22158563›Full record

ArticleThe Journal of infectious diseases2012

Anthrax lethal and edema toxins fail to directly impair human platelet function.

Kassidy M Chauncey, Sarah E Szarowicz, Gurjit S Sidhu, Russell L During, Frederick S Southwick

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kassidy M ChaunceyDepartment of Medicine, University of Florida, Gainesville, FL 32610-0277, USA.
Sarah E Szarowicz
Gurjit S Sidhu
Russell L During
Frederick S Southwick
University of Florida · US

Funding

Anthrax Toxins Impair Phagocyte Actin-based MotilityR01AI064891 · NIAID · UNIVERSITY OF FLORIDA · PI SOUTHWICK, FREDERICK S · 2006 to 2010
$1.3M
NIAID NIH HHS R01 AI064891NIAID NIH HHS R01AI064891
6 · The paper itself

Abstract

Hemorrhage is a prominent clinical manifestation of systemic anthrax. Therefore, we have examined the effects of anthrax lethal and edema toxins on human platelets. We find that anthrax lethal toxin fails to cleave its target, mitogen-activated protein kinase 1, and anthrax edema toxin fails to increase intracellular cyclic adenosine monophosphate. Surface expression of toxin receptors tumor endothelial marker 8 and capillary morphogenesis gene 2, as well as coreceptor low density lipoprotein receptor-related protein 6 (LRP6), are markedly reduced, preventing toxin binding to platelets. Our studies suggest that the hemorrhagic clinical manifestations of systemic anthrax are unlikely to be caused by the direct binding and entry of anthrax toxins into human platelets.

Indexed as

AnimalsAntigens, BacterialBacterial ToxinsBlood PlateletsCyclic AMPGene Expression ProfilingHuman ExperimentationHumansLow Density Lipoprotein Receptor-Related Protein-6Membrane ProteinsMiceMicrofilament ProteinsMitogen-Activated Protein Kinase 1Neoplasm ProteinsProteolysisReceptors, Cell Surfaceanthrax toxinAntigens, BacterialANTXR1 protein, humanANTXR2 protein, humanBacterial ToxinsCyclic AMPLow Density Lipoprotein Receptor-Related Protein-6LRP6 protein, humanMAPK1 protein, humanMembrane ProteinsMicrofilament ProteinsMitogen-Activated Protein Kinase 1Neoplasm ProteinsReceptors, Cell SurfaceReceptors, Peptide

Identifiers

PMID22158563
PMCPMC3256950
OpenAlexW2097008796

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.