ArticleThe Journal of investigative dermatology2012
Host phenotype characteristics and MC1R in relation to early-onset basal cell carcinoma.
Article in The Journal of investigative dermatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Molecular Mechanisms and Targeted Therapies of Advanced Basal Cell Carcinoma.International journal of molecular sciences · 2022Review
- Risk of Nonmelanoma Skin Cancers and Parkinson's Disease-Meta-Analysis and Systematic Review.Cancers · 2021Review
- Basal Cell Carcinoma: A Comprehensive Review.International journal of molecular sciences · 2020Review
- Cross-sectional assessment of ultraviolet radiation-related behaviors among young people after a diagnosis of melanoma or basal cell carcinoma.Journal of the American Academy of Dermatology · 2018Article
- The activation of PPARγ by 2,4,6-Octatrienoic acid protects human keratinocytes from UVR-induced damages.Scientific reports · 2017Article
- Predictors of tanning dependence in white non-Hispanic females and males.Journal of the European Academy of Dermatology and Venereology : JEADV · 2017Article
- CDKN2A and MC1R variants found in Cypriot patients diagnosed with cutaneous melanoma.Journal of genetics · 2017Article
- Distinct Histologic Subtypes and Risk Factors for Early Onset Basal Cell Carcinoma: A Population-Based Case Control Study from New Hampshire.The Journal of investigative dermatology · 2016Article
- Family history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotype.Cancer epidemiology · 2015Article
- MC1R gene variants and non-melanoma skin cancer: a pooled-analysis from the M-SKIP project.British journal of cancer · 2015Article
- Indoor tanning and the MC1R genotype: risk prediction for basal cell carcinoma risk in young people.American journal of epidemiology · 2015Article
- Alcohol intake and early-onset basal cell carcinoma in a case-control study.The British journal of dermatology · 2014Article
- Indoor tanning in businesses and homes and risk of melanoma and nonmelanoma skin cancer in 2 US case-control studies.Journal of the American Academy of Dermatology · 2014Article
- Novel gene identified in an exome-wide association study of tanning dependence.Experimental dermatology · 2014Article
- Systemic glucocorticoid use and early-onset basal cell carcinoma.Annals of epidemiology · 2014Article
- Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case-control study.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2014Article
- Indoor tanning and tanning dependence in young people after a diagnosis of basal cell carcinoma.JAMA dermatology · 2013Article
- Indoor tanning and risk of early-onset basal cell carcinoma.Journal of the American Academy of Dermatology · 2012Article
- Lifetime history of indoor tanning in young people: a retrospective assessment of initiation, persistence, and correlates.BMC public health · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Basal cell carcinoma (BCC) incidence is increasing, particularly among adults under the age of 40 years. Pigment-related characteristics are associated with BCC in older populations, but epidemiologic studies among younger individuals and analyses of phenotype-genotype interactions are limited. We examined self-reported phenotypes and melanocortin 1 receptor gene (MC1R) variants in relation to early-onset BCC. BCC cases (n=377) and controls with benign skin conditions (n=390) under the age of 40 years were identified through Yale's Dermatopathology database. Factors most strongly associated with early-onset BCC were skin reaction to first summer sun for 1 hour (severe sunburn vs. tan odds ratio (OR)=12.27, 95% confidence interval (CI)=4.08-36.94) and skin color (very fair vs. olive OR=11.06, 95% CI=5.90-20.74). Individuals with two or more MC1R non-synonymous variants were 3.59 times (95% CI=2.37-5.43) more likely to have BCC than those without non-synonymous variants. All host characteristics and MC1R were more strongly associated with multiple BCC case status (37% of cases) than a single BCC case status. MC1R, number of moles, skin reaction to first summer sun for 1 hour, and hair and skin color were independently associated with BCC. BCC risk conferred by MC1R tended to be stronger among those with darker pigment phenotypes, traditionally considered to be at low risk of skin cancer.
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