ArticleThe pharmacogenomics journal2013
Inter-ethnic differences in lymphocyte sensitivity to glucocorticoids reflect variation in transcriptional response.
Article in The pharmacogenomics journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Trial
- A female-biased gene expression signature of dominance in cooperatively breeding meerkats.Molecular ecology · 2024Article
- Transcriptional reprogramming of infiltrating neutrophils drives lung pathology in severe COVID-19 despite low viral load.Blood advances · 2023Article
- Corticosteroid Treatment-Resistance in Myasthenia Gravis.Frontiers in neurology · 2022Review
- Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity.ERJ open research · 2021Article
- Population pharmacodynamic modeling of intramuscular and oral dexamethasone and betamethasone effects on six biomarkers with circadian complexities in Indian women.Journal of pharmacokinetics and pharmacodynamics · 2021Observational
- Racial Differences in Immunological Landscape Modifiers Contributing to Disparity in Prostate Cancer.Cancers · 2019Review
- Racial discrimination and leukocyte glucocorticoid sensitivity: Implications for birth timing.Social science & medicine (1982) · 2018Article
- The Growth Arrest-Specific Transcript 5 (GAS5) and Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1): Novel Markers Involved in Multiple Sclerosis.International journal of molecular and cellular medicine · 2018Article
- Colonic transcriptional response to 1α,25(OH)The Journal of steroid biochemistry and molecular biology · 2017Article
- Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry.The Journal of allergy and clinical immunology · 2016Review
- Patterns of Transcriptional Response to 1,25-Dihydroxyvitamin D3 and Bacterial Lipopolysaccharide in Primary Human Monocytes.G3 (Bethesda, Md.) · 2016Article
- Estimating the Ages of Selection Signals from Different Epochs in Human History.Molecular biology and evolution · 2016Article
- Mapping Variation in Cellular and Transcriptional Response to 1,25-Dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells.PloS one · 2016Article
- A high-throughput RNA-seq approach to profile transcriptional responses.Scientific reports · 2015Article
- Peripheral blood IRF1 expression as a marker for glucocorticoid sensitivity.Pharmacogenetics and genomics · 2015Article
- Expression quantitative trait locus analysis for translational medicine.Genome medicine · 2015Review
- Combining genetic and nongenetic biomarkers to realize the promise of pharmacogenomics for inflammatory diseases.Pharmacogenomics · 2014Review
- Genetic mapping with multiple levels of phenotypic information reveals determinants of lymphocyte glucocorticoid sensitivity.American journal of human genetics · 2013Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Glucocorticoids (GCs) are steroid hormones widely used as pharmaceutical interventions, which act mainly by regulating gene expression levels. A large fraction of patients (∼30%), especially those of African descent, show a weak response to treatment. To interrogate the contribution of variable transcriptional response to inter-ethnic differences, we measured in vitro lymphocyte GC sensitivity (LGS) and transcriptome-wide response to GCs in peripheral blood mononuclear cells from African-American (AA) and European-American (EA) healthy donors. We found that transcriptional response after 8 h treatment was significantly correlated with variation in LGS within and between populations. We found that NFKB1, a gene previously found to predict LGS within populations, was more strongly downregulated in EAs on average. NFKB1 could not completely explain population differences, however, and we found an additional 177 genes with population differences in the average log2 fold change (false discovery rate<0.05), most of which also showed a weaker transcriptional response in AAs. These results suggest that inter-ethnic differences in GC sensitivity reflect variation in transcriptional response at many genes, including regulators with large effects (for example, NFKB1) and numerous other genes with smaller effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.