ReviewTopics in magnetic resonance imaging : TMRI2010
Challenges of High-resolution Diffusion Imaging of the Human Medial Temporal Lobe in Alzheimer Disease.
Review in Topics in magnetic resonance imaging : TMRI, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Restriction spectrum imaging reveals decreased neurite density in patients with temporal lobe epilepsy.Epilepsia · 2016Article
- Anatomical, functional and molecular biomarker applications of magnetic resonance neuroimaging.Future neurology · 2015Article
- Quantitative MR evaluation of atrophy, as well as perfusion and diffusion alterations within hippocampi in patients with Alzheimer's disease and mild cognitive impairment.Medical science monitor : international medical journal of experimental and clinical research · 2013Article
- Ultra-high resolution diffusion tensor imaging of the microscopic pathways of the medial temporal lobe.NeuroImage · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The human medial temporal lobe performs an essential role in memory formation and retrieval. Diseases involving the hippocampus such as Alzheimer disease present a unique opportunity for advanced imaging techniques to detect abnormalities at an early stage. In particular, it is possible that diffusion imaging will measure abnormal microarchitecture beyond the realm of macroscopic imaging. However, this task is formidable because of the detailed anatomy of the medial temporal lobe, the difficulties in obtaining high-quality diffusion images of adequate resolution, and the challenges in diffusion data processing. Moreover, it is unclear if any differences will be significant for an individual patient or simply groups of patients. Successful endeavors will need to address each of these challenges in an integrated fashion. The rewards of such analysis may be detection of microscopic disease in vivo, which could represent a landmark accomplishment for the field of neuroradiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.