ArticleThe American journal of gastroenterology2012
Pancreas divisum is not a cause of pancreatitis by itself but acts as a partner of genetic mutations.
Article in The American journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 4 of them syntheses that pooled it.
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Who cites it
71 citing papers in PubMed, 4 syntheses or guidelines pooled it, 245 citations in OpenAlex.
- The Prevalence of Pancreas Divisum and Its Association with Pancreatic Diseases: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Stent placement in pancreatic disease, when, which and why? - a current perspective.Frontiers in gastroenterology (Lausanne, Switzerland) · 2022Pooled it
- Germline Variants and Risk for Pancreatic Cancer: A Systematic Review and Emerging Concepts.Pancreas · 2018Pooled it
- Academic Pancreas Centers of Excellence: Guidance from a multidisciplinary chronic pancreatitis working group at PancreasFest.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]Guideline
- Geometric simplification by ductal unification of dual pancreatic ducts during pancreaticojejunostomy.BMC surgery · 2026Article
- Therapeutic application of feeding strategies in chronic pancreatitis: the potential for jejunal feeding and elemental diet to modulate pancreatic secretion to alleviate painful symptoms.Frontiers in physiology · 2026Review
- Mechanism and treatment of pancreatic duct stones.World journal of gastrointestinal surgery · 2025Review
- Chronic Pancreatitis and Pancreas Divisum: A Case Report of Recurrent Management Challenges.Cureus · 2025Article
- Endoscopic Management of Recurrent Acute Pancreatitis.Journal of clinical medicine · 2025Review
- Early Chronic Pancreatitis Findings by Endoscopic Ultrasonography (EUS) in Asymptomatic Patients with Pancreas Divisum.Diagnostics (Basel, Switzerland) · 2025Article
- Prospective study on outcomes of endotherapy for pancreatic divisum in patients of recurrent acute pancreatitis.Endoscopy international open · 2025Article
- Choledochal Cyst and Pancreas Divisum: A Case Report.The American journal of case reports · 2024Article
- Idiopathic acute pancreatitis (IAP)-a review of the literature and algorithm proposed for the diagnostic work-up of IAP.Translational gastroenterology and hepatology · 2024Review
- Case Report: Chronic pancreatitis in children as the cumulative effect of bilio-pancreatic abnormalities and genetic mutations.Frontiers in pediatrics · 2024Article
- Pancreas divisum unmasked: a case report.The Pan African medical journal · 2024Article
- Genetics and Genomics of Chronic Pancreatitis with a Focus on Disease Biology and Molecular Pathogenesis.Global medical genetics · 2023Review
- Genetic Investigations in Turkish Idiopathic Pancreatitis Patients Show Unique Characteristics.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023Article
- Periampullary tumors in a patient with pancreatic divisum and neurofibromatosis type 1: a case report.Hereditary cancer in clinical practice · 2023Article
- Incidence and Clinical Implications of Anatomical Variations in the Pancreas and Its Ductal System: A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2023Review
- Chronic pancreatitis caused by a HomozygousJournal of pediatric genetics · 2022Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe role of pancreas divisum (PD) as a cause of acute recurrent or chronic pancreatitis (AR/CP) is still a matter of debate.
methodsThe aims of this study were to evaluate the frequency of PD diagnosed using magnetic resonance cholangiopancreatography (MRCP) in patients with AR/CP of unknown origin (n=40) after careful exclusion of all known causes and to test the hypothesis of an interaction between anatomical (PD) and functional genetic anomalies (SPINK1, PRSS1, or CFTR gene mutations or polymorphisms (n=19, 25, and 30, respectively)) that could result in AR/CP. Patients with alcohol-induced pancreatitis (n=29) and subjects who had MRCP for a nonpancreatic disease (n=45) served as controls.
resultsPD frequency was 7% in subjects without pancreatic disease, 7% in patients with alcohol-induced pancreatitis, and 5, 16, 16, and 47% in those with idiopathic, and PRSS1-, SPINK1-, and CFTR-associated pancreatitis, respectively (P<0.0001). There was no significant difference between idiopathic pancreatitis and the two control groups. The frequency of PD was higher in patients with CFTR gene-associated pancreatitis as compared with those with idiopathic and alcoholic pancreatitis (P<0.0001) and with those with SPINK1 and PRSS1 gene-associated pancreatitis (P<0.02).
conclusionsThe frequency of PD was not different in patients with idiopathic pancreatitis as compared with controls, demonstrating that PD by itself is not a cause of pancreatitis. PD frequency was higher in patients with genetic pancreatitis, especially in those with CFTR mutations or polymorphisms, suggesting a cumulative effect of these two cofactors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.