Evidence map›Paper›PMID 22157880›Full record

Trial reportMedicine and science in sports and exercise2012

Effect of exercise training modality on C-reactive protein in type 2 diabetes.

Damon L Swift, Neil M Johannsen, Conrad P Earnest, Steven N Blair, Timothy S Church

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medicine and science in sports and exercise, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00458133 (Health Benefits of Aerobic and Resistance Training in Individuals With Type 2 Diabetes), which is not on this map. Cited by 30 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 10 pooled it
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00458133 nacompletednot on this map

Health Benefits of Aerobic and Resistance Training in Individuals With Type 2 Diabetes

TypeinterventionalSponsorPennington Biomedical Research CenterRan2007 to 2010Enrolled262ConditionsType 2 DiabetesArmsexercise
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 10 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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  20. Role of C-Reactive Protein in Kidney Diseases.Kidney diseases (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Damon L SwiftDepartment of Preventive Medicine, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA. Damon.Swift@pbrc.edu
Neil M Johannsen
Conrad P Earnest
Steven N Blair
Timothy S Church
Pennington Biomedical Research Center · USUniversity of South Carolina · US

Funding

Health benefits of Aerobic and Resistance Training in individuals with DiabetesR01DK068298 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI CHURCH, TIMOTHY STEPHEN · 2006 to 2009
$2.3M
NIDDK NIH HHS R01 DK068298
6 · The paper itself

Abstract

purposeType 2 diabetes is associated with increased risk of cardiovascular disease and elevated C-reactive protein (CRP) levels. Aerobic exercise training has been shown to improve CRP; however, there are limited data evaluating the effect of other exercise training modalities (aerobic, resistance, or combination training) in individuals with type 2 diabetes.

methodsParticipants (n = 204) were randomized to an aerobic exercise (aerobic), resistance exercise (resistance), or a combination of both (combination) for 9 months. CRP was evaluated at baseline and at follow-up.

resultsBaseline CRP was correlated with fat mass, waist circumference, body mass index, and VO(2peak) ̇(P < 0.05). CRP was not reduced after aerobic (0.16 mg·L(-1), 95% confidence interval (CI) = -1.0 to 1.3 mg·L(-1)), resistance (-0.03 mg·L(-1), 95% CI = -1.1 to 1.0 mg·L(-1)), or combination (-0.49 mg·L(-1), 95% CI = -1.5 to 0.6 mg·L(-1)) training compared to control (0.35 mg·L(-1), 95% CI = -1.0 to 1.7 mg·L(-1)). Changes in fasting glucose (r = 0.20, P = 0.009), glycated hemoglobin (HbA1c) (r = 0.21, P = 0.005), and fat mass (r = 0.19, P = 0.016) were associated with reductions in CRP but not with change in fitness or weight (P > 0.05). There were significant trends observed for CRP among tertiles of change in HbA1c (P = 0.009) and body fat (P = 0.040).

conclusionsAerobic, resistance, or a combination of both did not reduce CRP levels in individuals with type 2 diabetes. However, exercise-related improvements in HbA1c, fasting glucose, and fat mass were associated with reductions in CRP.

Indexed as

Analysis of VarianceBlood GlucoseBody CompositionBody Mass IndexChi-Square DistributionC-Reactive ProteinDiabetes Mellitus, Type 2Exercise TestExercise TherapyFemaleGlycated HemoglobinHumansMaleMiddle AgedOxygen ConsumptionTreatment OutcomeBlood GlucoseC-Reactive ProteinGlycated Hemoglobin

Identifiers

PMID22157880
PMCPMC3345306
OpenAlexW2088529045

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.