ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2012
Neural correlates associated with cognitive decline in late-life depression.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Evidence for Structural and Functional Alterations of Frontal-Executive and Corticolimbic Circuits in Late-Life Depression and Relationship to Mild Cognitive Impairment and Dementia: A Systematic Review.Frontiers in neuroscience · 2020Pooled it
- Structural Brain Changes Associated With Risky Drinking in Late-Life Depression.The American journal of geriatric psychiatry. Open science, education, and practice · 2025Article
- Cognitive Performance Deficits Are Associated with Clinically Significant Depression Symptoms in Older US Adults.International journal of environmental research and public health · 2023Article
- Brain-based mechanisms of late-life depression: Implications for novel interventions.Seminars in cell & developmental biology · 2021Review
- Predicting conversion to Alzheimer's disease among individual high-risk patients using the Characterizing AD Risk Events index model.CNS neuroscience & therapeutics · 2020Article
- Cognitive Control Network Homogeneity and Executive Functions in Late-Life Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Disruption of Neural Homeostasis as a Model of Relapse and Recurrence in Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019Review
- The Newly Normed SKT Reveals Differences in Neuropsychological Profiles of Patients with MCI, Mild Dementia and Depression.Diagnostics (Basel, Switzerland) · 2019Article
- Article
- Amygdala network dysfunction in late-life depression phenotypes: Relationships with symptom dimensions.Journal of psychiatric research · 2015Article
- Subjective cognitive concerns and neuropsychiatric predictors of progression to the early clinical stages of Alzheimer disease.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2014Article
- Imbalanced hippocampal functional networks associated with remitted geriatric depression and apolipoprotein E ε4 allele in nondemented elderly: a preliminary study.Journal of affective disorders · 2014Article
- Depression in cognitive impairment.Current psychiatry reports · 2013Review
- Organic bases of late-life depression: a critical update.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- The age-by-disease interaction hypothesis of late-life depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2013Review
- Neural signatures of the response to emotional distraction: a review of evidence from brain imaging investigations.Frontiers in human neuroscience · 2013Article
- Depression and cognitive impairment in older adults.Current psychiatry reports · 2012Review
- Depressive symptoms and mild cognitive impairment in the elderly: an ominous combination.Biological psychiatry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesPersistent cognitive impairment (PCI) after remission of depressive symptoms is a major adverse outcome of late-life depression (LLD). The purpose of this study was to examine neural substrates associated with PCI in LLD.
designLongitudinal study.
settingOutpatient depression treatment study at Duke University.
participantsTwenty-three patients with LLD completed a 2-year follow-up study, and were in a remitted or partially remitted state at Year 2.
methodsAt first entry to the study (Year 0), all participants had a functional magnetic resonance imaging scan while performing an emotional oddball task. For the purpose of this report, the primary functional magnetic resonance imaging outcome was brain activation during target detection, which is a measure of executive function. The Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery was used to assess cognitive status yearly, and the Montgomery-Åsberg Depression Rating Scale was used to assess severity of depression at Year 0 and every 6 months thereafter for 2 years. We investigated changes in brain activation at Year 0 associated with PCI over 2 years.
resultsPatients with PCI at the 2-year follow-up date had significantly decreased activation at Year 0 in the dorsal anterior cingulate cortex, hippocampus, inferior frontal cortex, and insula compared to non-PCI patients.
conclusionsOur results suggest individuals who have LLD with PCI have decreased activation in the similar neural networks associated with the development of Alzheimer disease among nondepressed individuals. Measuring neural activity in these regions in individuals with LLD may help identify patients at-risk for cognitive impairment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.