ArticleCell cycle (Georgetown, Tex.)2012
APOBEC3 proteins and genomic stability: the high cost of a good defense.
Article in Cell cycle (Georgetown, Tex.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Decoding osteosarcoma from heterogeneity to precision therapy.Discover oncology · 2025Review
- Mechanisms underlying the compromised clinical efficacy of interferon in clearing HBV.Virology journal · 2024Review
- LOXL2 Expression Status Is Correlated With Molecular Characterizations of Cervical Carcinoma and Associated With Poor Cancer Survival via Epithelial-Mesenchymal Transition (EMT) Phenotype.Frontiers in oncology · 2020Article
- Review
- USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication.eLife · 2019Article
- Cytidine deaminase Apobec3a induction in fallopian epithelium after exposure to follicular fluid.Gynecologic oncology · 2017Article
- Avoidance of APOBEC3B-induced mutation by error-free lesion bypass.Nucleic acids research · 2017Article
- Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma.Blood · 2016Article
- APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication.Cell reports · 2016Article
- APOBEC3A damages the cellular genome during DNA replication.Cell cycle (Georgetown, Tex.) · 2016Article
- APOBEC3A deaminates transiently exposed single-strand DNA during LINE-1 retrotransposition.eLife · 2014Article
- Article
- Construction and characterization of an infectious replication competent clone of porcine endogenous retrovirus from Chinese miniature pigs.Virology journal · 2013Article
- APOBEC3 cytidine deaminases in double-strand DNA break repair and cancer promotion.Cancer research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The human APOBEC3 family of cytidine deaminases constitutes a cellular intrinsic defense mechanism that is effective against a range of viruses and retro-elements. While it is well established that these enzymes are powerful mutators of viral DNA, the possibility that their activity could threaten the integrity of the host genome has only recently begun to be investigated. Here, we discuss the implications of new evidence suggesting that APOBEC3 proteins can mediate the deamination of cellular DNA. The maintenance of genomic integrity in the face of this potential off-target activity must require high fidelity DNA repair and strict regulation of APOBEC3 gene expression and enzyme activity. Conversely, the ability of specific members of the APOBEC3 family to activate DNA damage signaling pathways might also reflect another way that these proteins contribute to the host immune response.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.