Trial reportJournal of dental research2012
Efficacy of chlorhexidine varnish for the prevention of adult caries: a randomized trial.
Trial report in Journal of dental research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention of Adult Caries Study
Povidone Iodine to Prevent Early Childhood Caries
Who cites it
11 citing papers in PubMed.
- Visual scoring of non cavitated caries lesions and clinical trial efficiency, testing xylitol in caries-active adults.Community dentistry and oral epidemiology · 2014Trial
- Effects of common disinfectants on biofilm formation and eradication inFrontiers in cellular and infection microbiology · 2026Article
- Preventive measures and perceived challenges in delivering oral health care for elderly patients: a survey of dental hygienists in Norway.Acta odontologica Scandinavica · 2025Article
- Are the mutans streptococci still considered relevant to understanding the microbial etiology of dental caries?BMC oral health · 2018Article
- Root caries prevention via sodium fluoride, chlorhexidine and silver diamine fluoride in vitro.Odontology · 2018Article
- Fluorides and Other Preventive Strategies for Tooth Decay.Dental clinics of North America · 2018Review
- Article
- Targeted antimicrobial treatment to re-establish a healthy microbial flora for long-term protection.Advances in dental research · 2012Review
- Perspectives on PACS: where is caries prevention clinical research going?Journal of dental research · 2012Article
- A comparative, randomized, controlled study on clinical efficacy and dental staining reduction of a mouthwash containing Chlorhexidine 0.20% and Anti Discoloration System (ADS).Annali di stomatologiaReview
- Catechin-incorporated dental copolymers inhibit growth of Streptococcus mutans.Journal of applied oral science : revista FOBArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
The Prevention of Adult Caries Study, an NIDCR-funded multicenter, double-blind, randomized clinical trial, enrolled 983 adults (aged 18-80 yrs) at high risk for developing caries (20 or more intact teeth and 2 or more lesions at screening) to test the efficacy of a chlorhexidine diacetate 10% weight per volume (w/v) dental coating (CHX). We excluded participants for whom the study treatment was contraindicated or whose health might affect outcomes or ability to complete the study. Participants were randomly assigned to receive either the CHX coating (n = 490) or a placebo control (n = 493). Coatings were applied weekly for 4 weeks and a fifth time 6 months later. The primary outcome (total net D(1-2)FS increment) was the sum of weighted counts of changes in tooth surface status over 13 months. We observed no significant difference between the two treatment arms in either the intention-to-treat or per-protocol analyses. Analysis of 3 protocol-specified secondary outcomes produced similar findings. This trial failed to find that 10% (w/v) chlorhexidine diacetate coating was superior to placebo coating for the prevention of new caries (Clinicaltrials.gov registration number NCT00357877).
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.