ArticleJournal of endocrinological investigation2011
High-intensity focused ultrasound as an alternative to the surgical approach in primary hyperparathyroidism: a preliminary experience.
Article in Journal of endocrinological investigation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Parathyroid thermal ablation in 2023: the advent of a third wave for primary hyperparathyroidism.European radiology · 2024Article
- Radiofrequency ablation as a treatment modality for primary hyperparathyroidism: a systematic literature review.Gland surgery · 2024Review
- Bone Turnover Markers in Response to Ultrasound-Guided Microwave Ablation for Primary Hyperparathyroidism.Frontiers in endocrinology · 2021Article
- Minimally Invasive Treatment for Benign Parathyroid Lesions: Treatment Efficacy and Safety Based on Nodule Characteristics.Korean journal of radiology · 2020Article
- Comparison of microwave ablation treatments in patients with renal secondary and primary hyperparathyroidism.Renal failure · 2020Article
- Nodular Thyroid Disease in the Era of Precision Medicine.Frontiers in endocrinology · 2019Review
- Parathyroid ultrasonography: the evolving role of the radiologist.Ultrasonography (Seoul, Korea) · 2015Review
- US-guided high-intensity focused ultrasound as a promising non-invasive method for treatment of primary hyperparathyroidism.European radiology · 2014Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurgery is the therapy of choice in primary hyperparathyroidism (PHPT), although other less invasive techniques have been used in the attempt to cure the disease. Recently, high-intensity focused ultrasound (HIFU), a totally non-invasive technique, has become available to cure solid tumors.
aimThe aim of this pilot study has been to assess the safety and efficacy of HIFU in symptomatic patients with PHPT. MATERIAL AND
methodsFour out of 31 patients with surgical indications within a cohort of 47-screened patients with PHPT were considered eligible for the study. All patients accepted to participate and were submitted to HIFU treatment in a single session. One patient was submitted to surgery after HIFU treatment. Patients were followed-up for 12 months after the procedure.
resultsA persistent or a partial remission of the disease, respectively, were obtained in 2 patients (50%), including the one who underwent surgery after HIFU treatment. Safety was assessed performing laryngoscopy in all patients after HIFU procedure. A transient vocal cord paralysis was observed in all patients treated by HIFU only. No permanent side effects were observed in the long term.
conclusionsHIFU might be a promising technique in treating PHPT, provided that further development of the software decreases the rate of side effects and improves the short- and long-term efficacy.
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